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  1. The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is a prospective, randomized, multicenter clinical trial of carotid endarterectomy (CEA) versus carotid artery stenting (CAS) as preve...

    Authors: Robert W Hobson II, Virginia J Howard, Thomas G Brott, George Howard, Gary S Roubin and Robert DG Ferguson

    Citation: Trials 2001 2:160

    Content type: Commentary

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  2. Long-term treatment with angiotensin-converting enzyme inhibitors reduces post-infarction morbidity and mortality in patients with left ventricular (LV) systolic dysfunction or symptomatic heart failure. Until...

    Authors: Vernon VS Bonarjee and Kenneth Dickstein

    Citation: Trials 2001 2:151

    Content type: Commentary

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  3. Randomized trials and observational studies, such as case-control studies, are often seen as opposing approaches. However, in many instances results obtained by different designs may complement each other. For...

    Authors: Frits R Rosendaal

    Citation: Trials 2001 2:109

    Content type: Commentary

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  4. Data quality assurance and quality control are critical to the effective conduct of a clinical trial. In the present commentary, we discuss our experience in a large, multicenter stroke trial. In addition to s...

    Authors: DeJuran Richardson and Shande Chen

    Citation: Trials 2001 2:115

    Content type: Commentary

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  5. Women may be at increased risk for venous thromboembolism (VTE) as compared with men. We studied the effects of genetic and biochemical markers of thrombophilia in women, in conjunction with other established ...

    Authors: Joel G Ray, Loralie J Langman, Marian J Vermeulen, Jovan Evrovski, Erik L Yeo and David EC Cole

    Citation: Trials 2001 2:141

    Content type: Research

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  6. During the past decade considerable research has been conducted into the use of cardiac troponins, their diagnostic capability and their potential to allow risk stratification in patients with acute chest pain...

    Authors: Britta U Goldmann, Robert H Christenson, Christian W Hamm, Thomas Meinertz and E Magnus Ohman

    Citation: Trials 2001 2:75

    Content type: Review

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  7. Results from the recent Dietary Approaches to Stop Hypertension (DASH)-Sodium trial provide the latest evidence concerning the effects of dietary patterns and sodium intake on blood pressure. Participants ate ...

    Authors: William M Vollmer, Frank M Sacks and Laura P Svetkey

    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:71

    Content type: Commentary

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  8. Various approaches for catheter ablation of focal initiators of atrial fibrillation or the substrate for maintaining atrial fibrillation have evolved over the past 5 years. Despite these advances, there are st...

    Authors: J Marcus Wharton

    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:67

    Content type: Commentary

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  9. The evidence base for drug treatment of hypertension is strong. Early trials using thiazide diuretics suggested a shortfall in prevention of coronary heart disease. The superiority of newer drugs has been wide...

    Authors: Gordon T McInnes

    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:63

    Content type: Commentary

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  10. Arteriosclerotic vascular disease manifests as heart disease, stroke, aortic aneurysms, and peripheral vascular disease, and is a growing problem world-wide. The preventive efforts made so far have demonstrate...

    Authors: W Virgil Brown

    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:12

    Content type: Commentary

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  11. Only a few randomized clinical trials have been performed so far in heart transplant recipients, mainly because of the relatively small number of heart transplants performed worldwide each year. The main focus...

    Authors: Maria Rosa Costanzo

    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:45

    Content type: Review

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  12. The Randomized Aldactone Evaluation Study (RALES) randomized 822 patients to receive 25 mg spironolactone daily and 841 to receive placebo. The primary endpoint was death from all causes. Randomization began o...

    Authors: Janet Wittes, Jolie Palensky, Debra Asner, Desmond Julian, Jean-Pierre Boissel, Curt D Furberg, Henri Kulbertus, Stuart Pocock and Barbara Roniker

    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:59

    Content type: Research

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  13. PREVENT was the first prospective, randomized placebo-controlled study of intracoronary beta radiotherapy with 32P. A total of 105 patients with de novo or restenotic lesions, treated by stenting or balloon angio...

    Authors: Albert E Raizner and Grzegorz L Kaluza

    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:16

    Content type: Commentary

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  14. The importance of low-density lipoprotein (LDL) control in the management of patients at high risk of cardiovascular events is unquestionable. The major statin trials have shown that the benefits of LDL loweri...

    Authors: Sergio Fazio and MacRae F Linton

    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:8

    Content type: Commentary

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  15. The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials recruit pathologic...

    Authors: Bruce G Charlton

    Citation: Current Controlled Trials in Cardiovascular Medicine 2001 2:2

    Content type: Commentary

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  16. As the population ages the number of elderly patients presenting with acute myocardial infarction (AMI) will continue to increase. There has been no head-to-head trial of thrombolytic therapy versus primary pe...

    Authors: Vincent S DeGeare and Cindy L Grines

    Citation: Trials 2000 1:146

    Content type: Commentary

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  17. Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials than that expect...

    Authors: Gavin J Blake and Paul M Ridker

    Citation: Trials 2000 1:161

    Content type: Review

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  18. 1. To assess the long-term effectiveness of a comprehensive cardiac rehabilitation programme on quality of life and survival in patients with a large spectrum of cardiovascular diseases (myocardial infarction,...

    Authors: Cornel Pater, Carl Ditlef Jacobsen, Arnfinn Rollag, Leiv Sandvik, Jan Erikssen and Else Karin Kogstad

    Citation: Trials 2000 1:177

    Content type: Research

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  19. Chronic heart failure (CHF) is a common condition with a poor prognosis. It is associated with poor exercise tolerance and debilitating symptoms. These symptoms appear to be associated with pathophysiological ...

    Authors: Andrew JS Coats

    Citation: Trials 2000 1:155

    Content type: Review

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  20. Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for the complex cardiovascular diseases of heart ...

    Authors: Andrea D Eckhart and Walter J Koch

    Citation: Trials 2000 1:131

    Content type: Commentary

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  21. Lipid disorders are associated with atherosclerotic vascular disease, and therapy is associated with a substantial reduction in cardiovascular events. Current approaches to the treatment of lipid disorders are...

    Authors: Masa-aki Kawashiri and Daniel J Rader

    Citation: Trials 2000 1:120

    Content type: Review

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  22. Despite the major advances in medical drug therapy, heart failure remains a syndrome associated with high mortality and morbidity. Biventricular or left ventricular (LV) short atrioventricular (AV) delay pacin...

    Authors: Jayne A Morris-Thurgood and Michael P Frenneaux

    Citation: Trials 2000 1:107

    Content type: Review

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  23. Surrogate outcomes are frequently used in cardiovascular disease research. A concern is that changes in surrogate markers may not reflect changes in disease outcomes. Two recent clinical trials (Heart and Estr...

    Authors: Ralph B D'Agostino Jr

    Citation: Trials 2000 1:76

    Content type: Commentary

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  24. Surrogate end-points of cardiovascular disease can provide useful information in cross-sectional, prospective and interventional studies. They provide information on association with risk factors, natural hist...

    Authors: Jonathan Valabhji and Robert S Elkeles

    Citation: Trials 2000 1:72

    Content type: Commentary

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