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  1. Due to language limitations, the abstract of journal article may be the only way for people of non-Chinese speaking countries to know about trials in traditional Chinese medicine (TCM). However, little is know...

    Authors: Ling Wang, Yulin Li, Jing Li, Mingming Zhang, Lin Xu, Wenming Yuan, Gang Wang and Sally Hopewell

    Citation: Trials 2010 11:75

    Content type: Methodology

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  2. Stroke is one of the most disabling and costly impairments of adulthood in the United States. Stroke patients clearly benefit from intensive inpatient care, but due to the high cost, there is considerable inte...

    Authors: Neale R Chumbler, Dorian K Rose, Patricia Griffiths, Patricia Quigley, Nancy McGee-Hernandez, Katherine A Carlson, Phyllis Vandenberg, Miriam C Morey, Jon Sanford and Helen Hoenig

    Citation: Trials 2010 11:74

    Content type: Study protocol

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  3. Quality of residential care for people with severe dementia is in urgent need of improvement. One reason for this may be the assumption that people with severe dementia are unaware of what is happening to them...

    Authors: Linda Clare, Robert T Woods, Rhiannon Whitaker, Barbara A Wilson and Murna Downs

    Citation: Trials 2010 11:73

    Content type: Study protocol

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  4. The challenge of Bipolar Disorder (BD) treatment is due to the complexity of the disease. Current guidelines represent an effort to help clinicians in their everyday practice but still have limitations, specia...

    Authors: Rodolfo N Campos, Luis F Costa, Danielle S Bio, Márcio G Soeiro de Souza, Carla RL Garcia, Frederico N Demétrio, Doris H Moreno and Ricardo A Moreno

    Citation: Trials 2010 11:72

    Content type: Study protocol

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  5. A recent Cochrane Review demonstrated the remarkable lack of reliable clinical trials of migraine treatments for children, especially for the two most prescribed preventative treatments in the UK, Propranolol and...

    Authors: Paul Silcocks, Diane Whitham and William Patrick Whitehouse

    Citation: Trials 2010 11:71

    Content type: Study protocol

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  6. Anemia is a risk factor for death, adverse cardiovascular outcomes and poor quality of life in patients with chronic kidney disease (CKD). Erythropoietin Stimulating Agents (ESA) are commonly used to increase ...

    Authors: Giovanni FM Strippoli

    Citation: Trials 2010 11:70

    Content type: Study protocol

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  7. Acute infectious diseases are major causes of short periods of days off from work, day care and school. These diseases are mainly caused by viruses and hands have a key role in their transmission. Thus, hypoth...

    Authors: Carita Savolainen-Kopra, Jaason Haapakoski, Piia A Peltola, Thedi Ziegler, Terttu Korpela, Pirjo Anttila, Ali Amiryousefi, Pentti Huovinen, Markku Huvinen, Heikki Noronen, Pia Riikkala, Merja Roivainen, Petri Ruutu, Juha Teirilä, Erkki Vartiainen and Tapani Hovi

    Citation: Trials 2010 11:69

    Content type: Study protocol

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  8. The optimization of preventive strategies in patients at high risk of cardiovascular events and the evaluation of bottlenecks and limitations of transferring current guidelines to the real world of clinical pr...

    Authors:

    Citation: Trials 2010 11:68

    Content type: Study protocol

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  9. Screening for abdominal aortic aneurysm (AAA) of men aged 65-74 years reduces the AAA-related mortality and is generally considered cost effective. Despite of this only a few national health care services have...

    Authors: Nikolaj Grøndal, Rikke Søgaard, Eskild W Henneberg and Jes S Lindholt

    Citation: Trials 2010 11:67

    Content type: Study protocol

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  10. Our objective was to report on the design and essentials of the Etoricoxib protocol- Preemptive and Postoperative Analgesia (EPPA) Trial, investigating whether preemptive analgesia with cox-2 inhibitors is more e...

    Authors: Johannes Fleckenstein, Sybille Kramer, Martin Offenbächer, Gabriel Schober, Herbert Plischke, Matthias Siebeck, Thomas Mussack, Rudolf Hatz, Lukas Lehmeyer, Philip M Lang, Bernhard Heindl, Peter Conzen and Dominik Irnich

    Citation: Trials 2010 11:66

    Content type: Study protocol

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  11. The subject of death and bereavement in the context of randomised controlled trials in neonatal or paediatric intensive care is under-researched. The objectives of this phase of the Bereavement and RAndomised ...

    Authors: Claire Snowdon, Sheila E Harvey, Peter Brocklehurst, Robert C Tasker, Martin P Ward Platt, Elizabeth Allen and Diana Elbourne

    Citation: Trials 2010 11:65

    Content type: Research

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  12. Public confidence in clinical trials has been eroded by data suppression, misrepresentation and manipulation. Although various attempts have been made to achieve universal trial registration- e.g., Declaration...

    Authors: Zhao-Xiang Bian and Tai-Xiang Wu

    Citation: Trials 2010 11:64

    Content type: Commentary

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  13. There is scope to improve the quality of life (QOL) of people with dementia living in residential care facilities (RCF). The DIRECT study will determine if delivery of education to General Practitioners (GPs) ...

    Authors: Christopher D Beer, Barbara Horner, Osvaldo P Almeida, Samuel Scherer, Nicola T Lautenschlager, Nick Bretland, Penelope Flett, Frank Schaper and Leon Flicker

    Citation: Trials 2010 11:63

    Content type: Study protocol

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  14. The standard of care for colorectal peritoneal carcinomatosis is evolving from chemotherapy to cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with disease limit...

    Authors: Robert T Ripley, Jeremy L Davis, Clinton D Kemp, Seth M Steinberg, Mary Ann Toomey and Itzhak Avital

    Citation: Trials 2010 11:62

    Content type: Study protocol

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  15. Statins have been proved to be effective in reduction of mortality and morbidity when started in the early secondary prevention in stabilized patients after acute coronary syndrome (ACS). The safety and effica...

    Authors: Petr Ostadal, David Alan, Jiri Vejvoda, Jiri Kukacka, Milan Macek, Petr Hajek, Martin Mates, Milan Kvapil, Jiri Kettner, Martin Wiendl, Ondrej Aschermann, Josef Slaby, Frantisek Holm, Peter Telekes, David Horak, Peter Blasko…

    Citation: Trials 2010 11:61

    Content type: Research

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  16. Associated with a tripling in obesity since 1970, type 2 diabetes mellitus (T2DM) in children has risen 9-10 fold. There is a critical need of protocols for trials to prevent T2DM in children.

    Authors: Lorrene D Ritchie, Sushma Sharma, Joanne P Ikeda, Rita A Mitchell, Aarthi Raman, Barbara S Green, Mark L Hudes and Sharon E Fleming

    Citation: Trials 2010 11:60

    Content type: Study protocol

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  17. To evaluate the use and reporting of adjusted analysis in randomised controlled trials (RCTs) and compare the quality of reporting before and after the revision of the CONSORT Statement in 2001.

    Authors: Ly-Mee Yu, An-Wen Chan, Sally Hopewell, Jonathan J Deeks and Douglas G Altman

    Citation: Trials 2010 11:59

    Content type: Review

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  18. Tackling neonatal mortality is essential for the achievement of the child survival millennium development goal. There are just under 4 million neonatal deaths, accounting for 38% of the 10.8 million deaths amo...

    Authors: Betty R Kirkwood, Alexander Manu, Charlotte Tawiah-Agyemang, Guus ten Asbroek, Thomas Gyan, Benedict Weobong, R Eric Lewandowski, Seyi Soremekun, Samuel Danso, Catherine Pitt, Kara Hanson, Seth Owusu-Agyei and Zelee Hill

    Citation: Trials 2010 11:58

    Content type: Study protocol

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  19. Chest pain is a common presenting complaint in the emergency department (ED). Despite the frequency with which clinicians evaluate patients with chest pain, accurately determining the risk of acute coronary sy...

    Authors: Meghan A Pierce, Erik P Hess, Jeffrey A Kline, Nilay D Shah, Maggie Breslin, Megan E Branda, Laurie J Pencille, Brent R Asplin, David M Nestler, Annie T Sadosty, Ian G Stiell, Henry H Ting and Victor M Montori

    Citation: Trials 2010 11:57

    Content type: Study protocol

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  20. Chronic (systolic) heart failure (CHF) represents a clinical syndrome with high individual and societal burden of disease. Multifaceted interventions like case management are seen as promising ways of improvin...

    Authors: Frank Peters-Klimm, Stephen Campbell, Katja Hermann, Cornelia U Kunz, Thomas Müller-Tasch and Joachim Szecsenyi

    Citation: Trials 2010 11:56

    Content type: Research

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  23. Almost all of the 820,000 people in the UK with dementia will experience Behavioural and Psychological Symptoms of Dementia (BPSD). However, research has traditionally focused on treating cognitive symptoms, t...

    Authors: Arlinda Cerga-Pashoja, David Lowery, Rahul Bhattacharya, Mark Griffin, Steve Iliffe, James Lee, Claire Leonard, Sue Ricketts, Lyn Strother, Fiona Waters, Craig W Ritchie and James Warner

    Citation: Trials 2010 11:53

    Content type: Study protocol

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  24. Outcome reporting bias (ORB) occurs when variables are selected for publication based on their results. This can impact upon the results of a meta-analysis, biasing the pooled treatment effect estimate.

    Authors: Kerry Dwan, Carrol Gamble, Ruwanthi Kolamunnage-Dona, Shabana Mohammed, Colin Powell and Paula R Williamson

    Citation: Trials 2010 11:52

    Content type: Methodology

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  25. Thrombolysis with intravenous rt-PA is currently the only approved acute therapy for ischemic stroke. Re-occlusion after initial recanalization occurs in up to 34% in patients treated with rt-PA, probably caus...

    Authors: SM Zinkstok, M Vermeulen, J Stam, RJ de Haan and YB Roos

    Citation: Trials 2010 11:51

    Content type: Study protocol

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  26. Furosemide is commonly prescribed in critically ill patients with acute kidney injury (AKI). Existing data from observational studies and small clinical trials have significant limitations and have reported co...

    Authors: Sean M Bagshaw, R T Noel Gibney, Finlay A McAlister and Rinaldo Bellomo

    Citation: Trials 2010 11:50

    Content type: Study protocol

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  27. The process for data collection in multicenter trials may be troublesome and expensive. We report our experience with the spreadsheet function in Googledocs for this purpose.

    Authors: Jacob Rosenberg, Nadia Abdelaal Henriksen and Lars Nannestad Jørgensen

    Citation: Trials 2010 11:49

    Content type: Methodology

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  28. Generalised anxiety disorder (GAD) is a high prevalence, chronic psychiatric disorder which commonly presents early in the lifespan. Internet e-health applications have been found to be successful in reducing ...

    Authors: Helen Christensen, Adam J Guastella, Andrew J Mackinnon, Kathleen M Griffiths, Claire Eagleson, Philip J Batterham, Kanupriya Kalia, Justin Kenardy, Kylie Bennett and Ian B Hickie

    Citation: Trials 2010 11:48

    Content type: Study protocol

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  29. A recently published systematic review indicated superiority of duodenum-preserving techniques when compared with pancreatoduodenectomy, for the treatment of patients with chronic pancreatitis in the head of t...

    Authors: Markus K Diener, Thomas Bruckner, Pietro Contin, Christopher Halloran, Matthias Glanemann, Hans Jürgen Schlitt, Joachim Mössner, Meinhard Kieser, Jens Werner, Markus W Büchler and Christoph M Seiler

    Citation: Trials 2010 11:47

    Content type: Study protocol

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  30. Psychological treatments for dementia are widely used in the UK and internationally, but only rarely have they been standardised, adequately evaluated or systematically implemented. There is increasing recogni...

    Authors: Elisa Aguirre, Aimee Spector, Juanita Hoe, Ian T Russell, Martin Knapp, Robert T Woods and Martin Orrell

    Citation: Trials 2010 11:46

    Content type: Study protocol

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  31. Editors from a number of medical journals lay out principles for journals considering publication of Comparative Effectiveness Research (CER). In order to encourage dissemination of this editorial, this articl...

    Authors: Harold C Sox, Mark Helfand, Jeremy Grimshaw, Kay Dickersin, David Tovey, J André Knottnerus and Peter Tugwell

    Citation: Trials 2010 11:45

    Content type: Editorial

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  32. The gap between the level of care recommended by evidence-based clinical practice guidelines and the actual care delivered to patients in practice has been well established. The Canadian Diabetes Association (...

    Authors: Baiju R Shah, Onil Bhattacharyya, Catherine Yu, Muhammad Mamdani, Janet A Parsons, Sharon E Straus and Merrick Zwarenstein

    Citation: Trials 2010 11:44

    Content type: Study protocol

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  33. We assessed the prevalence, and potential impact of, trials of pharmacological agents for acute stroke that were completed but not published in full. Failure to publish trial data is to be deprecated as it set...

    Authors: Lorna M Gibson, Miriam Brazzelli, Brenda M Thomas and Peter AG Sandercock

    Citation: Trials 2010 11:43

    Content type: Research

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  34. Basal cell carcinoma is the commonest human cancer. Despite increasing incidence it remains poorly researched. While not life threatening it can cause significant cosmetic disfigurement. Imiquimod, a cream whi...

    Authors: Mara Ozolins, Hywel C Williams, Sarah J Armstrong and Fiona J Bath-Hextall

    Citation: Trials 2010 11:42

    Content type: Study protocol

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  35. Patients undergoing major elective or urgent surgery are at high risk of death or significant morbidity. Measures to reduce this morbidity and mortality include pre-operative optimisation and use of higher lev...

    Authors: Brian H Cuthbertson, Marion K Campbell, Stephen A Stott, Luke Vale, John Norrie, John Kinsella, Jonathan Cook, Julie Brittenden and Adrian Grant

    Citation: Trials 2010 11:41

    Content type: Study protocol

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  36. Each year, worldwide about 530,000 women die from causes related to pregnancy and childbirth. Of the deaths 99% are in low and middle income countries. Obstetric haemorrhage is the leading cause of maternal mo...

    Authors: Haleema Shakur, Diana Elbourne, Metin Gülmezoglu, Zarko Alfirevic, Carine Ronsmans, Elizabeth Allen and Ian Roberts

    Citation: Trials 2010 11:40

    Content type: Study protocol

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  37. Recruitment to clinical trials can be challenging. We identified anonymous potential participants to an existing pragmatic randomised controlled depression trial to assess the feasibility of using routinely co...

    Authors: Joanna McGregor, Caroline Brooks, Padmaja Chalasani, Jude Chukwuma, Hayley Hutchings, Ronan A Lyons and Keith Lloyd

    Citation: Trials 2010 11:39

    Content type: Research

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  38. Insufficient blood pressure control is a frequent problem despite the existence of effective treatment. Insufficient adherence to self-monitoring as well as to therapy is a common reason. Blood pressure self-m...

    Authors: Claudia Steurer-Stey, Marco Zoller, Corinne Chmiel Moshinsky, Oliver Senn and Thomas Rosemann

    Citation: Trials 2010 11:38

    Content type: Study protocol

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  39. Reporting bias represents a major problem in the assessment of health care interventions. Several prominent cases have been described in the literature, for example, in the reporting of trials of antidepressan...

    Authors: Natalie McGauran, Beate Wieseler, Julia Kreis, Yvonne-Beatrice Schüler, Heike Kölsch and Thomas Kaiser

    Citation: Trials 2010 11:37

    Content type: Review

    Published on:

  40. Back pain, one of the most prevalent conditions afflicting American adults, is the leading reason for using complementary and alternative medicine (CAM) therapies. Yoga is an increasingly popular "mind-body" C...

    Authors: Karen J Sherman, Daniel C Cherkin, Andrea J Cook, Rene J Hawkes, Richard A Deyo, Robert Wellman and Partap S Khalsa

    Citation: Trials 2010 11:36

    Content type: Study protocol

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  41. African Americans with Type 2 diabetes (T2DM) have higher prevalence of diabetes, poorer metabolic control, and greater risk for complications and death compared to American Whites. Poor outcomes in African Am...

    Authors: Leonard E Egede, Joni L Strom, Valerie L Durkalski, Patrick D Mauldin and William P Moran

    Citation: Trials 2010 11:35

    Content type: Study protocol

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  42. Tinnitus is the perception of hearing a sound for which there is no external acoustic source. It is often associated with sudden, temporary hearing loss and has a clear impact on a patient's quality of life. D...

    Authors: Nam-Kwen Kim, Dong-Hyo Lee, Jung-Hun Lee, Yong-Leol Oh, In-Hwan Yoon, Eun-Sung Seo and Chung-Ho Lee

    Citation: Trials 2010 11:34

    Content type: Study protocol

    Published on:

  43. Just like you would not buy a car without key information such as service history, you would not "buy" a clinical trial report without key information such as concealment of allocation. Implementation of the u...

    Authors: Hywel C Williams

    Citation: Trials 2010 11:33

    Content type: Commentary

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  46. Psychotic disorders are a serious mental health problem. Intervention before the onset of psychosis might result in delaying the onset, reducing the impact or even preventing the first episode of psychosis. Th...

    Authors: Judith Rietdijk, Sara Dragt, Rianne Klaassen, Helga Ising, Dorien Nieman, Lex Wunderink, Philippe Delespaul, Pim Cuijpers, Don Linszen and Mark van der Gaag

    Citation: Trials 2010 11:30

    Content type: Study protocol

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  47. Pain is one of the most frequent and distressing symptoms in cancer patients. For the majority of the patients, sufficient pain relief can be obtained if adequate treatment is provided. However, pain remains o...

    Authors: Patrick Jahn, Maria Kitzmantel, Petra Renz, Ene Kukk, Oliver Kuss, Anette Thoke-Colberg, Ingrid Horn and Margarete Landenberger

    Citation: Trials 2010 11:29

    Content type: Study protocol

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  48. Recent cohort studies of randomised controlled trials have provided evidence of within-study selective reporting bias; where statistically significant outcomes are more likely to be more completely reported co...

    Authors: Joanne E McKenzie, G Peter Herbison, Paul Roth and Charlotte Paul

    Citation: Trials 2010 11:28

    Content type: Commentary

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  49. Pre-diabetes is a growing health concern where a large percentage of these patients develop full type 2 diabetes. Effective interventions on pre-diabetes can prevent or delay the occurrence or development of d...

    Authors: Hongbo Cao, Ming Ren, Liping Guo, Hongcai Shang, Junhua Zhang, Yuzhen Song, Hui Wang, Baohe Wang, Xiantao Li, Jing Hu, Xuemei Wang, Dehui Wang, Jianzong Chen, Shuanglei Li and Liming Chen

    Citation: Trials 2010 11:27

    Content type: Study protocol

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  50. Suicide, attempted suicide and suicidal thoughts are major public health problems worldwide. Effective face-to-face treatments are Cognitive Behavioural Therapy (CBT), Dialectical Behavioural Therapy (DBT) and...

    Authors: Bregje A J van Spijker, Annemieke van Straten and Ad J F M Kerkhof

    Citation: Trials 2010 11:25

    Content type: Study protocol

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