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  1. Over the last years, less invasive surgical techniques with soft tissue preservation for bone conduction hearing implants (BCHI) have been introduced such as the linear incision technique combined with a punch...

    Authors: Tim G. A. Calon, Marc van Hoof, Herbert van den Berge, Arthur J. G. de Bruijn, Joost van Tongeren, Janny R. Hof, Jan Wouter Brunings, Sofia Jonhede, Lucien J. C. Anteunis, Miranda Janssen, Manuela A. Joore, Marcus Holmberg, Martin L. Johansson and Robert J. Stokroos
    Citation: Trials 2016 17:540
  2. Individuals who are edentulous have a lower intake of fruit, vegetables, fiber, and protein compared with their dentate counterparts because tooth loss is accompanied by a decrease in ability to chew. Whether ...

    Authors: Yuriko Komagamine, Manabu Kanazawa, Maiko Iwaki, Ayami Jo, Hiroyuki Suzuki, Noriko Amagai and Shunsuke Minakuchi
    Citation: Trials 2016 17:539
  3. Since 1990, the lives of 48 million children under the age of 5 years have been saved because of increased investments in reducing child mortality. However, despite these unprecedented gains, 250 million child...

    Authors: Mark Tomlinson, Sarah Skeen, Marguerite Marlow, Lucie Cluver, Peter Cooper, Lynne Murray, Shoeshoe Mofokeng, Nathene Morley, Moroesi Makhetha, Sarah Gordon, Tonya Esterhuizen and Lorraine Sherr
    Citation: Trials 2016 17:538
  4. Transition-age youth have elevated rates of mental disorders, and they often do not receive services. This is a serious public health concern, as mental health conditions persist into adulthood. Continuing to ...

    Authors: Michelle R. Munson, Andrea Cole, Victoria Stanhope, Steven C. Marcus, Mary McKay, James Jaccard and Shelly Ben-David
    Citation: Trials 2016 17:537
  5. The prevalence of neonatal abstinence syndrome (NAS) is increasing globally resulting in an increased incidence of adverse neonatal outcomes and health system costs. Evidence regarding the effectiveness of NAS...

    Authors: Lauren E. Kelly, Lauren M. Jansson, Wendy Moulsdale, Jodi Pereira, Sarah Simpson, Astrid Guttman, Karel Allegaert, Lisa Askie, Henry Roukema, Thierry Lacaze, Jonathan M. Davis, Loretta Finnegan, Paula Williamson and Martin Offringa
    Citation: Trials 2016 17:536
  6. Most incisions following surgery heal by primary intention, with the edges of the wound apposed with sutures or clips. However, some wounds may break open or be left to heal from the bottom up (i.e. healing by...

    Authors: Catherine Arundel, Hannah Buckley, Emma Clarke, Nicky Cullum, Stephen Dixon, Jo Dumville, Caroline Fairhurst, Anna Firth, Eileen Henderson, Karen Lamb, Elizabeth McGinnis, Angela Oswald, Pedro Saramago Goncalves, Marta Soares, Nikki Stubbs, David Torgerson…
    Citation: Trials 2016 17:535
  7. Preliminary clinical studies on the single-implant mandibular overdenture (SIMO) have reported favorable results as an alternative to the conventional complete dentures for rehabilitation of the edentulous man...

    Authors: Túlio Eduardo Nogueira, Shahrokh Esfandiari and Cláudio Rodrigues Leles
    Citation: Trials 2016 17:533
  8. Rates of mental health disorders are significantly greater in children with physical illnesses than in physically well children. Children with neurological conditions, such as epilepsy, are known to have parti...

    Authors: Sophie Bennett, Isobel Heyman, Anna Coughtrey, Jess Simmonds, Sophia Varadkar, Terence Stephenson, Margaret DeJong and Roz Shafran
    Citation: Trials 2016 17:532
  9. Medical progress and the lifestyle modification have prolonged life expectancy, despite the development of chronic diseases. Support and care for older subjects are often provided by a network of informal care...

    Authors: Astrid Pozet, Catherine Lejeune, Magalie Bonnet, Sandrine Dabakuyo, Michèle Dion, Philippe Fagnoni, Maryse Gaimard, Geneviève Imbert, Virginie Nerich, Audrey Foubert, Morgane Chotard, Marie Bonin, Amélie Anota and Franck Bonnetain
    Citation: Trials 2016 17:531
  10. Heart failure (HF) is a common and disabling condition in older people. Randomized clinical trials and meta-analyses have clearly demonstrated that the long-term use of β-Blockers improves the outcome of patie...

    Authors: Kyungil Park and Tae-Ho Park
    Citation: Trials 2016 17:530
  11. Generalized tonic-clonic seizures (GTCSs) are the main risk factor for sudden unexpected death in epilepsy (SUDEP). Experimental and clinical data strongly suggest that the majority of SUDEP results from a pos...

    Authors: Sylvain Rheims, Luc Valton, Véronique Michel, Louis Maillard, Vincent Navarro, Philippe Convers, Fabrice Bartolomei, Arnaud Biraben, Arielle Crespel, Philippe Derambure, Bertrand de Toffol, Edouard Hirsch, Philippe Kahane, Martine Lemesle Martin, Didier Tourniaire, Sébastien Boulogne…
    Citation: Trials 2016 17:529
  12. The aim of this investigator-initiated trial is to evaluate the safety and efficacy of the novel Luminor® paclitaxel-coated drug-eluting balloon (DEB) catheter (iVascular, S.L.U., Barcelona, Spain) in inhibiti...

    Authors: U. Teichgräber, R. Aschenbach, D. Scheinert, T. Zeller, K. Brechtel, M. Thieme, E. Blessing, M. Treitl, M. Lichtenberg, P. von Flowtow, B. Vogel, M. Werk, V. Riambau, A. Wienke, T. Lehmann and S. Sixt
    Citation: Trials 2016 17:528

    The Erratum to this article has been published in Trials 2017 18:193

  13. About 2–3 % of the population participates in blood donation programmes. Each whole blood donation or ten apheresis donations cause a loss of 200–250 mg of iron. As a result, one of the most common risks of re...

    Authors: Susanne Macher, Camilla Drexler, Ines Lindenau, Nazanin Sareban, Peter Schlenke and Karin Amrein
    Citation: Trials 2016 17:527
  14. Nonpharmacologic interventions, such as cognitive training or physical exercise, are effective in improving cognitive functions for older adults with mild cognitive impairment (MCI). Some researchers have prop...

    Authors: Ya-yun Lee, Ching-yi Wu, Ching-hung Teng, Wen-chuin Hsu, Ku-chou Chang and Poyu Chen
    Citation: Trials 2016 17:526
  15. Internet-based self-help psychotherapy (IBT) could be an important alternative or supplement to ordinary face-to-face therapy. The findings of randomised controlled trials indicate that the effects of various ...

    Authors: Morten Fenger, Jane Lindschou, Christian Gluud, Per Winkel, Lise Jørgensen, Sten Kruse-Blinkenberg and Marianne Lau
    Citation: Trials 2016 17:525
  16. Study attrition has the potential to compromise a trial’s internal and external validity. The aim of the present study was to identify factors associated with participant attrition in a pilot trial of the effe...

    Authors: T. P. Thompson, C. J. Greaves, R. Ayres, P. Aveyard, F. C. Warren, R. Byng, R. S. Taylor, J. L. Campbell, M. Ussher, S. Michie, R. West and A. H. Taylor
    Citation: Trials 2016 17:524
  17. After a lesion to the central nervous system, many patients suffer from reduced walking capability. In the first rehabilitation phase, repeated walking exercises facilitate muscular strength and stimulate brai...

    Authors: Cathia Rossano and Philippe Terrier
    Citation: Trials 2016 17:523
  18. The INVESTIGATE-I study was designed to inform a future definitive randomised trial of invasive urodynamic testing, compared to basic clinical assessment with noninvasive tests prior to surgical treatment, in ...

    Authors: Paul Hilton, Brian S. Buckley, Elaine McColl, Denise Howel, Douglas G. Tincello and Catherine Brennand
    Citation: Trials 2016 17:522
  19. Human lactancy is a simple and cost-effective strategy that influences infant and maternal mortality rates. Skin-to-skin contact (SSC) is an immediate postpartum period strategy that has proven to benefit the ...

    Authors: Sergio Agudelo, Oscar Gamboa, Fabio Rodríguez, Sandra Cala, Nathalie Gualdrón, Evelyn Obando and María Lucía Padrón
    Citation: Trials 2016 17:521
  20. An anti-reflux catheter (ARC) may increase the tumor absorbed dose during radioembolization (RE) by elimination of particle reflux and its effects on hemodynamics. Since the catheter is fixed in a centro-lumin...

    Authors: Andor F. van den Hoven, Jip F. Prince, Rutger C. G. Bruijnen, Helena M. Verkooijen, Gerard C. Krijger, Marnix G. E. H. Lam and Maurice A. A. J. van den Bosch
    Citation: Trials 2016 17:520
  21. Post amputation, the complication of phantom limb pain (PLP) is prevalent and difficult to manage. This study aimed to determine whether it was feasible and acceptable to undertake a definitive multicentred ra...

    Authors: Esmé G. Trevelyan, Warren A. Turner, Lynn Summerfield-Mann and Nicola Robinson
    Citation: Trials 2016 17:519
  22. Atrial fibrillation is common in patients with structural heart disease who are undergoing cardiac surgery. Surgical CryoMaze has been shown to be an effective treatment in several trials, but success rates ha...

    Authors: Martin Eisenberger, Alan Bulava, Josef Kautzner, Petr Neuzil, Ales Mokracek, Jiri Hanis and Ladislav Dusek
    Citation: Trials 2016 17:518
  23. Glycated haemoglobin (HbA1c) is an important outcome measure in diabetes clinical trials. For multicentre designs, HbA1c can be measured locally at participating centres or by sending blood samples to a centra...

    Authors: Barbara N. Arch, Joanne Blair, Andrew McKay, John W. Gregory, Paul Newland and Carrol Gamble
    Citation: Trials 2016 17:517

    The Erratum to this article has been published in Trials 2017 18:164

  24. Postprandial glycaemic response affects cognitive and vascular function. The acute effect of breakfast glycaemic index on vascular parameters is not sufficiently known. Also, the influence of breakfasts with d...

    Authors: Natalia Sanchez-Aguadero, Luis Garcia-Ortiz, Maria C. Patino-Alonso, Sara Mora-Simon, Manuel A. Gomez-Marcos, Rosario Alonso-Dominguez, Benigna Sanchez-Salgado and Jose I. Recio-Rodriguez
    Citation: Trials 2016 17:516
  25. Around 35–45 % of people in contact with services for a first episode of psychosis are using cannabis. Cannabis use is associated with delays in remission, poorer clinical outcomes, significant increases in th...

    Authors: Sonia Johnson, Luke Sheridan Rains, Steven Marwaha, John Strang, Thomas Craig, Tim Weaver, Paul McCrone, Michael King, David Fowler, Stephen Pilling, Louise Marston, Rumana Z. Omar, Meghan Craig and Mark Hinton
    Citation: Trials 2016 17:515
  26. Low back pain is a major clinical and public health problem, with limited evidence-based treatments. Low-dose antidepressants are commonly used to treat pain in chronic low back pain. However, their efficacy i...

    Authors: Donna M. Urquhart, Anita E. Wluka, Malcolm R. Sim, Maurits van Tulder, Andrew Forbes, Stephen J. Gibson, Carolyn Arnold, Chris Fong, Shane N. Anthony and Flavia M. Cicuttini
    Citation: Trials 2016 17:514
  27. Although Traditional Chinese Medicine (TCM) has been widely used in clinical settings, a major challenge that remains in TCM is to evaluate its efficacy scientifically. This randomized controlled trial aims to...

    Authors: Ying Zhang, Jin Sun, Yun-Jiao Zhang, Qian-Yun Chai, Kang Zhang, Hong-Li Ma, Xiao-Ke Wu and Jian-Ping Liu
    Citation: Trials 2016 17:512
  28. Hypertension is one of the most important and well-known risk factors for cardiovascular diseases. Unfortunately, in spite of effective treatments, adherence to the regular use of drugs and other nondrug treat...

    Authors: Mahnaz Ashoorkhani, Ali Bozorgi, Reza Majdzadeh, Hamed Hosseini, Ali Yoonessi, Ali Ramezankhani and Hassan Eftekhar
    Citation: Trials 2016 17:511
  29. Most children in Western populations do not meet recommendations for fish consumption. Oily fish is an important source of n-3 long-chain polyunsaturated fatty acids (LCPUFA), which reduce blood pressure and p...

    Authors: Camilla T. Damsgaard, Lotte Lauritzen, Hanne Hauger, Stine Vuholm, Marie N. Teisen, Christian Ritz, Max Hansen, Janni Niclasen and Christian Mølgaard
    Citation: Trials 2016 17:510
  30. Young women exposed to a high hereditary breast and ovarian cancer (HBOC) risk are particularly vulnerable. They are ignored by health prevention measures but exposed to a stream of contradictory information (...

    Authors: Fabrice Kwiatkowski, Pascal Dessenne, Claire Laquet, Jean-Pierre Daures, Mathilde Gay-Bellile and Yves-Jean Bignon
    Citation: Trials 2016 17:509
  31. Loss of upper limb function affects up to 85 % of acute stroke patients. Recovery of upper limb function requires regular intensive practise of specific upper limb tasks. To enhance intensity of practice inter...

    Authors: Sarah A. Moore, Ruth Da Silva, Madelaine Balaam, Lianne Brkic, Dan Jackson, Dan Jamieson, Thomas Ploetz, Helen Rodgers, Lisa Shaw, Frederike van Wijck and Christopher Price
    Citation: Trials 2016 17:508
  32. Arising from the relevance of sensorimotor training in the therapy of nonspecific low back pain patients and from the value of individualized therapy, the present trial aims to test the feasibility and efficac...

    Authors: Daniel Niederer, Lutz Vogt, Pia-Maria Wippert, Anne-Katrin Puschmann, Ann-Christin Pfeifer, Marcus Schiltenwolf, Winfried Banzer and Frank Mayer
    Citation: Trials 2016 17:507

    The Erratum to this article has been published in Trials 2017 18:60

  33. Denture adhesives, characterized as medical products in 1935 by the American Dental Association, have been considered useful adjuncts for improving denture retention and stability. However, many dentists in Ja...

    Authors: Suguru Kimoto, Yasuhiko Kawai, Atsuko Gunji, Hisatomo Kondo, Taro Nomura, Tomohiko Murakami, Akito Tsuboi, Guang Hong, Shunsuke Minakuchi, Yusuke Sato, Gaku Ohwada, Tetsuya Suzuki, Katsuhiko Kimoto, Noriyuki Hoshi, Makiko Saita, Yoshikazu Yoneyama…
    Citation: Trials 2016 17:506
  34. Currently, a cervical esophagogastric anastomosis (CEA) is often performed after minimally invasive esophagectomy (MIE). However, the CEA is associated with a considerable incidence of anastomotic leakage requ...

    Authors: Frans van Workum, Stefan A. W. Bouwense, Misha D. P. Luyer, Grard A. P. Nieuwenhuijzen, Donald L. van der Peet, Freek Daams, Ewout A. Kouwenhoven, Marc J van Det, Frits J. H. van den Wildenberg, Fatih Polat, Suzanne S. Gisbertz, Mark I. van Berge Henegouwen, Joos Heisterkamp, Barbara S. Langenhoff, Ingrid S. Martijnse, Janneke P. Grutters…
    Citation: Trials 2016 17:505
  35. Amblyopia is a common neurodevelopmental disorder of vision that is characterised by visual impairment in one eye and compromised binocular visual function. Existing evidence-based treatments for children incl...

    Authors: Cindy X. Guo, Raiju J. Babu, Joanna M. Black, William R. Bobier, Carly S. Y. Lam, Shuan Dai, Tina Y. Gao, Robert F. Hess, Michelle Jenkins, Yannan Jiang, Lionel Kowal, Varsha Parag, Jayshree South, Sandra Elfride Staffieri, Natalie Walker, Angela Wadham…
    Citation: Trials 2016 17:504
  36. Depression is a common antenatal mental disorder and is associated with an increased risk of adverse effects on the fetus and significant morbidity for the mother; if untreated it can also continue into the po...

    Authors: Kylee Trevillion, Jill Domoney, Andrew Pickles, Debra Bick, Sarah Byford, Margaret Heslin, Jeannette Milgrom, Rachel Mycroft, Carmine Pariante, Elizabeth Ryan, Myra Hunter and Louise Michele Howard
    Citation: Trials 2016 17:503
  37. Patients with chronic obstructive pulmonary disease (COPD) are often nonadherent with medications and have poor inhaler technique. Community pharmacists can help to improve health-related quality of life and o...

    Authors: Erin Davis, Carlo Marra, John-Michael Gamble, Jamie Farrell, Joe Lockyer, J. Mark FitzGerald, Waseem Abu-Ashour, Charlie Gillis and John Hawboldt
    Citation: Trials 2016 17:502
  38. The number of knee arthroplasties performed each year is steadily increasing. Although the outcome is generally favourable, up to 15 % fail to achieve a satisfactory clinical outcome which may indicate that th...

    Authors: Karen L. Barker, David Beard, Andrew Price, Francine Toye, Martin Underwood, Avril Drummond, Gary Collins, Susan Dutton, Helen Campbell, Nicola Kenealy, Jon Room and Sarah E. Lamb
    Citation: Trials 2016 17:501

    The Update to this article has been published in Trials 2018 19:638

  39. Patient-ventilator asynchrony is a common problem in mechanically ventilated patients with acute respiratory failure. It is assumed that asynchronies worsen lung function and prolong the duration of mechanical...

    Authors: Jesús Villar, Javier Belda, Jesús Blanco, Fernando Suarez-Sipmann, José Manuel Añón, Lina Pérez-Méndez, Carlos Ferrando, Dácil Parrilla, Raquel Montiel, Ruth Corpas, Elena González-Higueras, David Pestaña, Domingo Martínez, Lorena Fernández, Marina Soro, Miguel Angel García-Bello…
    Citation: Trials 2016 17:500
  40. Asthma is one of the commonest chronic diseases in the UK. Acute exacerbations of asthma are unpredictable, disruptive and frightening. They cause considerable morbidity and account for a large component of th...

    Authors: Andrew Skeggs, Tricia McKeever, Lelia Duley, Eleanor Mitchell, Lucy Bradshaw, Kevin Mortimer, Samantha Walker, Steve Parrott, Andrew Wilson, Ian Pavord, Chris Brightling, Mike Thomas, David Price, Graham Devereux, Bernard Higgins, Tim Harrison…
    Citation: Trials 2016 17:499
  41. Clinically significant psychological distress in pregnancy is common, with epidemiological research suggesting that between 15 and 25 % of pregnant women experience elevated symptoms of stress, anxiety, and de...

    Authors: Lianne M. Tomfohr-Madsen, Tavis S. Campbell, Gerald F. Giesbrecht, Nicole L. Letourneau, Linda E. Carlson, Joshua W. Madsen and Sona Dimidjian
    Citation: Trials 2016 17:498
  42. Sociodemographic characteristics are associated with participating in cancer screening and trials. We compared the characteristics of those responding with those not responding to a single invitation for prost...

    Authors: Eleanor I. Walsh, Emma L. Turner, J. Athene Lane, Jenny L. Donovan, David E. Neal, Freddie C. Hamdy and Richard M. Martin
    Citation: Trials 2016 17:497
  43. The use of the electronic medical record (EMR) system in recruitment in clinical trials has the potential for providing a very reliable and cost-effective recruiting methodology which may improve participant r...

    Authors: Valery S. Effoe, Jeffrey A. Katula, Julienne K Kirk, Carolyn F Pedley, Linda Y. Bollhalter, W. Mark Brown, Margaret R. Savoca, Stedman T. Jones, Janet Baek and Alain G. Bertoni
    Citation: Trials 2016 17:496
  44. Patients with type 2 diabetes (T2DM) are at increased risk for macrovascular events as well as for microvascular complications. There is evidence that in patients with coronary artery disease (CAD), about 35 %...

    Authors: Norbert J. Tripolt, Felix Aberer, Regina Riedl, Barbara Hutz, Jasmin Url, Gudrun Dimsity, Andreas Meinitzer, Tatjana Stojakovic, Ronald Hödl, Marianne Brodmann, Franz Hafner and Harald Sourij
    Citation: Trials 2016 17:495
  45. Trials increasingly experience problems in recruiting participants. Understanding the causes of poor recruitment is critical to developing solutions. We interviewed people who had declined a trial of an innova...

    Authors: Adwoa Hughes-Morley, Bridget Young, Roelie J. Hempel, Ian T. Russell, Waquas Waheed and Peter Bower
    Citation: Trials 2016 17:494
  46. The nutritional status and health of mothers influence the growth and development of infants during pregnancy and postnatal life. Interventions that focus on improving the nutritional status and lifestyle of m...

    Authors: Janis Baird, Mary Barker, Nicholas C. Harvey, Wendy Lawrence, Christina Vogel, Megan Jarman, Rufia Begum, Tannaze Tinati, Pamela Mahon, Sofia Strommer, Taylor Rose, Hazel Inskip and Cyrus Cooper
    Citation: Trials 2016 17:493
  47. The high prevalence of hepatitis B virus (HBV) imposes a huge burden of hepatocellular carcinoma (HCC) in Asia. Surgical resection remains an important therapeutic strategy for HCC. Hepatic inflow occlusion, k...

    Authors: Yinzhe Xu, Jiye Chen, Hongguang Wang, Hui Zheng, Dan Feng, Aiqun Zhang, Jianjun Leng, Weidong Duan, Zhanyu Yang, Mingyi Chen, Xianjie Shi, Shouwang Cai, Wenbin Ji, Kai Jiang, Wenzhi Zhang, Yongliang Chen…
    Citation: Trials 2016 17:492
  48. Maternal obesity is associated with increased risks of adverse pregnancy-related complications and outcomes for both mothers and infants. Overweight and obese women have an increased risk of pregnancy-induced ...

    Authors: Sofie Ingdam Halkjaer, Lisbeth Nilas, Emma Malchau Carlsen, Dina Cortes, Thórhallur Ingi Halldórsson, Sjúrdur Frodi Olsen, Anders Elm Pedersen, Karen Angeliki Krogfelt and Andreas Munk Petersen
    Citation: Trials 2016 17:491

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