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  1. Content type: Study protocol

    In the developmental stage of laparoscopic cholecystectomy (LC) it was considered 'unsafe' or 'technically difficult' to perform laparoscopic cholecystectomy for acute cholecystitis (AC). With increasing exper...

    Authors: Fausto Catena, Luca Ansaloni, Salomone Di Saverio, Filippo Gazzotti, Federico Coccolini and Antonio Daniele Pinna

    Citation: Trials 2009 10:34

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  2. Content type: Methodology

    A subgroup of clinical trial subjects identified by baseline characteristics is a proper subgroup while a subgroup determined by post randomization events or measures is an improper subgroup. Both types of sub...

    Authors: Karim F Hirji and Morten W Fagerland

    Citation: Trials 2009 10:33

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  3. Content type: Study protocol

    The incidence of gallstones and gallbladder sludge is known to be higher in patients after gastrectomy than in general population. This higher incidence is probably related to surgical dissection of the vagus ...

    Authors: Marco Farsi, Marco Bernini, Lapo Bencini, Egidio Miranda, Roberto Manetti, Giovanni de Manzoni, Giuseppe Verlato, Daniele Marrelli, Corrado Pedrazzani, Francesco Roviello, Alberto Marchet, Luigi Cristadoro, Leonardo Gerard and Renato Moretti

    Citation: Trials 2009 10:32

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  4. Content type: Study protocol

    One third to two thirds of people with schizophrenia have persistent psychotic symptoms despite clozapine treatment. Under real-world circumstances, the need to provide effective therapeutic interventions to p...

    Authors: Michela Nosè, Simone Accordini, Paola Artioli, Francesco Barale, Corrado Barbui, Rossella Beneduce, Domenico Berardi, Gerardo Bertolazzi, Bruno Biancosino, Alfredo Bisogno, Raffaella Bivi, Filippo Bogetto, Marianna Boso, Alberto Bozzani, Piera Bucolo, Marcello Casale…

    Citation: Trials 2009 10:31

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  5. Content type: Research

    Amlexanox has been developed as a 5 percent topical oral paste for the treatment of patients with recurrent aphthous stomatitis (RAS) in most European countries. However, it is not yet available in China and h...

    Authors: Wenxia Meng, Yi Dong, Jie Liu, Zhi Wang, Xiaobo Zhong, Ruiyang Chen, Hongmei Zhou, Mei Lin, Lu Jiang, Feng Gao, Tao Xu, Qianming Chen and Xin Zeng

    Citation: Trials 2009 10:30

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  6. Content type: Study protocol

    Medication errors are an important cause of morbidity and mortality in primary care.

    Authors: Anthony J Avery, Sarah Rodgers, Judith A Cantrill, Sarah Armstrong, Rachel Elliott, Rachel Howard, Denise Kendrick, Caroline J Morris, Scott A Murray, Robin J Prescott, Kathrin Cresswell and Aziz Sheikh

    Citation: Trials 2009 10:28

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    The Erratum to this article has been published in Trials 2010 11:23

  7. Content type: Research

    Although crossover trials enjoy wide use, standards for analysis and reporting have not been established. We reviewed methodological aspects and quality of reporting in a representative sample of published cro...

    Authors: Edward J Mills, An-Wen Chan, Ping Wu, Andy Vail, Gordon H Guyatt and Douglas G Altman

    Citation: Trials 2009 10:27

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  8. Content type: Study protocol

    Telephone quit lines are accessible to many smokers and are used to engage motivated smokers to make quit attempts. Smoking cessation counselling provided via telephone can either be reactive (i.e. primarily i...

    Authors: Tim Coleman, Andy McEwen, Linda Bauld, Janet Ferguson, Paula Lorgelly and Sarah Lewis

    Citation: Trials 2009 10:26

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  9. Content type: Study protocol

    Many studies have already reported encouraging results in the prophylactic therapy of migraine by acupuncture, but there seems to be a lack of high quality randomized controlled trials from China. We design an...

    Authors: Yan Zhang, Linpeng Wang, Huilin Liu, Nan Li, Jingdao Li and Jinghong Yi

    Citation: Trials 2009 10:25

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  10. Content type: Study protocol

    Fibromyalgia is a prevalent and disabling disorder characterized by widespread pain and other symptoms such as insomnia, fatigue or depression. Catastrophization is considered a key clinical symptom in fibromy...

    Authors: Javier García-Campayo, Antoni Serrano-Blanco, Baltasar Rodero, Rosa Magallón, Marta Alda, Eva Andrés, Juan V Luciano and Yolanda López del Hoyo

    Citation: Trials 2009 10:24

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  11. Content type: Study protocol

    Anorexia nervosa is a serious eating disorder leading to high morbidity and mortality as a result of both malnutrition and suicide. The seriousness of the disorder requires extensive knowledge of effective tre...

    Authors: Beate Wild, Hans-Christoph Friederich, Gaby Gross, Martin Teufel, Wolfgang Herzog, Katrin E Giel, Martina de Zwaan, Henning Schauenburg, Carmen Schade-Brittinger, Helmut Schäfer and Stephan Zipfel

    Citation: Trials 2009 10:23

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  12. Content type: Study protocol

    Older adults who live in rural areas experience significant disparities in health status and access to mental health care. "Telepsychology," (also referred to as "telepsychiatry," or "telemental health") repre...

    Authors: Leonard E Egede, Christopher B Frueh, Lisa K Richardson, Ronald Acierno, Patrick D Mauldin, Rebecca G Knapp and Carl Lejuez

    Citation: Trials 2009 10:22

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  13. Content type: Study protocol

    The prevalence of depression in patients with acute coronary syndrome, i.e. myocardial infarction and unstable angina, is higher than in the general population. The prevalence of anxiety is higher as well. Bot...

    Authors: Baiba Hedegaard Hansen, Jamal Abed Hanash, Alice Rasmussen, Jørgen Fischer Hansen and Morten Birket-Smith

    Citation: Trials 2009 10:20

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  14. Content type: Study protocol

    Many studies have attempted to determine the "best" anaesthetic technique for neurosurgical procedures in patients without intracranial hypertension. So far, no study comparing intravenous (IA) with volatile-base...

    Authors: Giuseppe Citerio, Maria Grazia Franzosi, Roberto Latini, Serge Masson, Simona Barlera, Stefano Guzzetti and Antonio Pesenti

    Citation: Trials 2009 10:19

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  15. Content type: Study protocol

    Depression Care for People with Cancer is a complex intervention delivered by specially trained cancer nurses, under the supervision of a psychiatrist. It is given as a supplement to the usual care for depressio...

    Authors: Jane Walker, Jim Cassidy and Michael Sharpe

    Citation: Trials 2009 10:18

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  16. Content type: Study protocol

    Tourette Syndrome (TS) is a neurological condition presenting chronic motor and phonic tics, and important degree of comorbidity. Considered an uncommon illness, it first becomes apparent during childhood. Cur...

    Authors: Rafael Garcia-Lopez, Emilio Perea-Milla, Cesar Ruiz Garcia, Francisco Rivas-Ruiz, Julio Romero-Gonzalez, Jose L Moreno, Vicente Faus, Guadalupe del Castillo Aguas and Juan C Ramos Diaz

    Citation: Trials 2009 10:16

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  17. Content type: Study protocol

    Hypertension affects 29% of the adult U.S. population and is a leading cause of heart disease, stroke, and kidney failure. Despite numerous effective treatments, only 53% of people with hypertension are at goa...

    Authors: Rowena J Dolor, William S Yancy Jr, William F Owen, David B Matchar, Gregory P Samsa, Kathryn I Pollak, Pao-Hwa Lin, Jamy D Ard, Maxwell Prempeh, Heather L McGuire, Bryan C Batch, William Fan and Laura P Svetkey

    Citation: Trials 2009 10:13

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  18. Content type: Research

    Metformin has had a 'black box' contraindication in diabetic patients with heart failure (HF), but many believe it to be the treatment of choice in this setting. Therefore, we attempted to conduct a pilot stud...

    Authors: Dean T Eurich, Ross T Tsuyuki, Sumit R Majumdar, Finlay A McAlister, Richard Lewanczuk, Marcelo C Shibata and Jeffrey A Johnson

    Citation: Trials 2009 10:12

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  19. Content type: Study protocol

    Non-pharmacological, non-surgical interventions are recommended as the first line of treatment for osteoarthritis (OA) of the hip and knee. There is evidence that exercise therapy is effective for reducing pai...

    Authors: J Haxby Abbott, M Clare Robertson, Joanne E McKenzie, G David Baxter, Jean-Claude Theis and A John Campbell

    Citation: Trials 2009 10:11

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  20. Content type: Study protocol

    Almost 50% of Americans have elevated low-density lipoprotein cholesterol (LDL-C). The behaviors required to lower LDL-C levels may be difficult to adhere to if they are inconsistent with spouses' health pract...

    Authors: Corrine I Voils, William S Yancy Jr, Stacey Kovac, Cynthia J Coffman, Morris Weinberger, Eugene Z Oddone, Amy Jeffreys, Santanu Datta and Hayden B Bosworth

    Citation: Trials 2009 10:10

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  21. Content type: Study protocol

    Laparoscopy-assisted vaginal hysterectomy is one of the definite methods for the treatment of symptomatic uterine fibroids with lesser intraoperative bleeding and shorter hospitalization compared with abdomina...

    Authors: Hee Seung Kim, Jae Weon Kim, Mi-Kyung Kim, Hyun Hoon Chung, Taek Sang Lee, Yong-Tark Jeon, Yong Beom Kim, Hye Won Jeon, Young Ho Yun, Noh Hyun Park, Yong Sang Song and Soon-Beom Kang

    Citation: Trials 2009 10:8

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  22. Content type: Erratum

    Authors: Caroline Laurence, Angela Gialamas, Lisa Yelland, Tanya Bubner, Philip Ryan, Kristyn Willson, Briony Glastonbury, Janice Gill, Mark Shephard and Justin Beilby

    Citation: Trials 2009 10:7

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    The original article was published in Trials 2008 9:50

  23. Content type: Study protocol

    An abundance of literature is dedicated to research for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Most, is in the area of pharmacological therapies with less emphasis in psychotherapy a...

    Authors: Fay Karpouzis, Henry Pollard and Rod Bonello

    Citation: Trials 2009 10:6

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  24. Content type: Study protocol

    The Tehran Lipid and Glucose Study (TLGS) is a long term integrated community-based program for prevention of non-communicable disorders (NCD) by development of a healthy lifestyle and reduction of NCD risk fa...

    Authors: Fereidoun Azizi, Arash Ghanbarian, Amir Abbas Momenan, Farzad Hadaegh, Parvin Mirmiran, Mehdi Hedayati, Yadollah Mehrabi and Saleh Zahedi-Asl

    Citation: Trials 2009 10:5

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  25. Content type: Study protocol

    There is no recommendation to screen ferritin level in blood donors, even though several studies have noted the high prevalence of iron deficiency after blood donation, particularly among menstruating females....

    Authors: Baptiste Pedrazzini, Sophie Waldvogel, Jacques Cornuz, Paul Vaucher, Raphael Bize, Jean-Daniel Tissot, Alain Pecoud and Bernard Favrat

    Citation: Trials 2009 10:4

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  26. Content type: Commentary

    Flaws in research papers are common but it may require arduous detective work to unravel them. Checklists are helpful, but many inconsistencies will only be revealed through repeated cross-checks of every litt...

    Authors: Peter C Gøtzsche

    Citation: Trials 2009 10:2

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  27. Content type: Methodology

    Assessing the quality of included trials is a central part of a systematic review. Many check-list type of instruments for doing this exist. Using a trial of antibiotic treatment for acute otitis media, Burke ...

    Authors: Karim F Hirji

    Citation: Trials 2009 10:1

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  28. Content type: Study protocol

    Whiplash injuries are an important public health problem that is associated with significant disability and high health care utilization. Recent cohort studies suggest that physician care may be the most effec...

    Authors: Pierre Côté, J David Cassidy, Simon Carette, Eleanor Boyle, Heather M Shearer, Maja Stupar, Carlo Ammendolia, Gabrielle van der Velde, Jill A Hayden, Xiaoqing Yang, Maurits van Tulder and John W Frank

    Citation: Trials 2008 9:75

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  29. Content type: Study protocol

    Adhesive small intestine occlusion [ASIO] is an important cause of hospital admission placing a substantial burden on healthcare systems worldwide. Often times, ASIO is associated with significant morbidity an...

    Authors: Fausto Catena, Luca Ansaloni, Augusto Lauro, Giorgio Ercolani, Luigi D'Alessandro and Antonio Pinna

    Citation: Trials 2008 9:74

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  30. Content type: Study protocol

    Pelvic inflammatory disease (PID) is common and can lead to tubal factor infertility, ectopic pregnancy or chronic pelvic pain. Despite major UK government investment in the National Chlamydia Screening Progra...

    Authors: Pippa Oakeshott, Sally Kerry, Helen Atherton, Adamma Aghaizu, Sima Hay, David Taylor-Robinson, Ian Simms and Phillip Hay

    Citation: Trials 2008 9:73

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  31. Content type: Study protocol

    Experimental studies have shown that ultrasound contrast agents enhance the effectiveness of thrombolytic agents in the presence of ultrasound in vitro and in vivo. Recently, we have launched a clinical pilot stu...

    Authors: Jeroen Slikkerveer, Pieter A Dijkmans, Gertjan T Sieswerda, Pieter AFM Doevendans, Arie PJ van Dijk, Freek WA Verheugt, Thomas R Porter and Otto Kamp

    Citation: Trials 2008 9:72

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  32. Content type: Research

    Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2), however, its clinical efficacies on oral malodor have been evaluated only with organoleptic measurem...

    Authors: Kayoko Shinada, Masayuki Ueno, Chisato Konishi, Sachiko Takehara, Sayaka Yokoyama and Yoko Kawaguchi

    Citation: Trials 2008 9:71

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  33. Content type: Study protocol

    Hot flushes are the most frequent climacteric symptom and a major cause of suffering among menopausal women. The condition negatively influences many aspects of women's lives. To date, conventional hormone rep...

    Authors: Kun-Hyung Kim, Kyung-Won Kang, Hee-Jung Jung, Ji-Eun Park, So-Young Jung, Jun-Yong Choi and Sun-Mi Choi

    Citation: Trials 2008 9:70

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  34. Content type: Methodology

    Standards for reporting clinical trials have improved the transparency of patient-important research. The Consolidated Standards of Reporting Trials (CONSORT) published an extension to address noninferiority a...

    Authors: Oghenowede Eyawo, Chia-Wen Lee, Beth Rachlis and Edward J Mills

    Citation: Trials 2008 9:69

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  35. Content type: Study protocol

    Magnetic Resonance Imaging (MRI) of patients with implanted cardiac devices is currently considered hazardous due to potential for electromagnetic interference to the patient and pacemaker system. With approxi...

    Authors: Richard Sutton, Emanuel Kanal, Bruce L Wilkoff, David Bello, Roger Luechinger, Inge Jenniskens, Michael Hull and Torsten Sommer

    Citation: Trials 2008 9:68

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  36. Content type: Study protocol

    Panic disorder (PD) is a common, severe and persistent mental disorder, associated with a high degree of distress and occupational and social disability. A substantial proportion of the population experiences ...

    Authors: Peter Meulenbeek, Godelief Willemse, Filip Smit, Anton van Balkom, Philip Spinhoven and Pim Cuijpers

    Citation: Trials 2008 9:67

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  37. Content type: Study protocol

    Twenty to 30 percent of all transient ischaemic attacks and ischaemic strokes involve tissue supplied by the vertebrobasilar circulation. Atherosclerotic stenosis ≥ 50% in the vertebral artery accounts for ver...

    Authors: A Compter, HB van der Worp, WJ Schonewille, JA Vos, A Algra, TH Lo, WPThM Mali, FL Moll and LJ Kappelle

    Citation: Trials 2008 9:65

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  38. Content type: Letter

    There is wide recognition that pragmatic randomised trials are the best vehicle for economic evaluation. This is because trials provide the best chance of ensuring internal validity, not least through the rigo...

    Authors: Rhiannon T Edwards, Barry Hounsome, Pat Linck and Ian T Russell

    Citation: Trials 2008 9:64

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  39. Content type: Study protocol

    TB and HIV form a deadly synergy in much of the developing world, especially Africa. Interventions to reduce the impact of these diseases at community level are urgently needed. This paper presents the design ...

    Authors: Helen M Ayles, Charalambos Sismanidis, Nulda Beyers, Richard J Hayes and Peter Godfrey-Faussett

    Citation: Trials 2008 9:63

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  40. Content type: Study protocol

    Osteoporosis-related fractures are a significant public health concern. Interventions that increase detection and treatment of osteoporosis, as well as prevention of fractures and falls, are substantially unde...

    Authors: PM Ciaschini, SE Straus, LR Dolovich, RA Goeree, KM Leung, CR Woods, GM Zimmerman, SR Majumdar, S Spadafora, LA Fera and HN Lee

    Citation: Trials 2008 9:62

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  41. Content type: Study protocol

    A full-thickness macular hole (FTMH) is a common retinal condition associated with impaired vision. Randomised controlled trials (RCTs) have demonstrated that surgery, by means of pars plana vitrectomy and pos...

    Authors: Noemi Lois, Jennifer Burr, John Norrie, Luke Vale, Jonathan Cook and Alison McDonald

    Citation: Trials 2008 9:61

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  42. Content type: Study protocol

    Totally Implantable Access Ports (TIAP) are being extensively used world-wide and can be expected to gain further importance with the introduction of new neoadjuvant and adjuvant treatments in oncology. Two di...

    Authors: Philip Knebel, Lars Fischer, Eva Cremonese, Ruben Lopez-Benitez, Ulrike Stampfl, Boris Radeleff, Hans-Ulrich Kauczor, Markus W Büchler and Christoph M Seiler

    Citation: Trials 2008 9:60

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