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  1. Content type: Study protocol

    Many studies have attempted to determine the "best" anaesthetic technique for neurosurgical procedures in patients without intracranial hypertension. So far, no study comparing intravenous (IA) with volatile-base...

    Authors: Giuseppe Citerio, Maria Grazia Franzosi, Roberto Latini, Serge Masson, Simona Barlera, Stefano Guzzetti and Antonio Pesenti

    Citation: Trials 2009 10:19

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  2. Content type: Study protocol

    Depression Care for People with Cancer is a complex intervention delivered by specially trained cancer nurses, under the supervision of a psychiatrist. It is given as a supplement to the usual care for depressio...

    Authors: Jane Walker, Jim Cassidy and Michael Sharpe

    Citation: Trials 2009 10:18

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  3. Content type: Study protocol

    Tourette Syndrome (TS) is a neurological condition presenting chronic motor and phonic tics, and important degree of comorbidity. Considered an uncommon illness, it first becomes apparent during childhood. Cur...

    Authors: Rafael Garcia-Lopez, Emilio Perea-Milla, Cesar Ruiz Garcia, Francisco Rivas-Ruiz, Julio Romero-Gonzalez, Jose L Moreno, Vicente Faus, Guadalupe del Castillo Aguas and Juan C Ramos Diaz

    Citation: Trials 2009 10:16

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  4. Content type: Study protocol

    Hypertension affects 29% of the adult U.S. population and is a leading cause of heart disease, stroke, and kidney failure. Despite numerous effective treatments, only 53% of people with hypertension are at goa...

    Authors: Rowena J Dolor, William S Yancy Jr, William F Owen, David B Matchar, Gregory P Samsa, Kathryn I Pollak, Pao-Hwa Lin, Jamy D Ard, Maxwell Prempeh, Heather L McGuire, Bryan C Batch, William Fan and Laura P Svetkey

    Citation: Trials 2009 10:13

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  5. Content type: Research

    Metformin has had a 'black box' contraindication in diabetic patients with heart failure (HF), but many believe it to be the treatment of choice in this setting. Therefore, we attempted to conduct a pilot stud...

    Authors: Dean T Eurich, Ross T Tsuyuki, Sumit R Majumdar, Finlay A McAlister, Richard Lewanczuk, Marcelo C Shibata and Jeffrey A Johnson

    Citation: Trials 2009 10:12

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  6. Content type: Study protocol

    Non-pharmacological, non-surgical interventions are recommended as the first line of treatment for osteoarthritis (OA) of the hip and knee. There is evidence that exercise therapy is effective for reducing pai...

    Authors: J Haxby Abbott, M Clare Robertson, Joanne E McKenzie, G David Baxter, Jean-Claude Theis and A John Campbell

    Citation: Trials 2009 10:11

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  7. Content type: Study protocol

    Almost 50% of Americans have elevated low-density lipoprotein cholesterol (LDL-C). The behaviors required to lower LDL-C levels may be difficult to adhere to if they are inconsistent with spouses' health pract...

    Authors: Corrine I Voils, William S Yancy Jr, Stacey Kovac, Cynthia J Coffman, Morris Weinberger, Eugene Z Oddone, Amy Jeffreys, Santanu Datta and Hayden B Bosworth

    Citation: Trials 2009 10:10

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  8. Content type: Study protocol

    Laparoscopy-assisted vaginal hysterectomy is one of the definite methods for the treatment of symptomatic uterine fibroids with lesser intraoperative bleeding and shorter hospitalization compared with abdomina...

    Authors: Hee Seung Kim, Jae Weon Kim, Mi-Kyung Kim, Hyun Hoon Chung, Taek Sang Lee, Yong-Tark Jeon, Yong Beom Kim, Hye Won Jeon, Young Ho Yun, Noh Hyun Park, Yong Sang Song and Soon-Beom Kang

    Citation: Trials 2009 10:8

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  9. Content type: Erratum

    Authors: Caroline Laurence, Angela Gialamas, Lisa Yelland, Tanya Bubner, Philip Ryan, Kristyn Willson, Briony Glastonbury, Janice Gill, Mark Shephard and Justin Beilby

    Citation: Trials 2009 10:7

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    The original article was published in Trials 2008 9:50

  10. Content type: Study protocol

    An abundance of literature is dedicated to research for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Most, is in the area of pharmacological therapies with less emphasis in psychotherapy a...

    Authors: Fay Karpouzis, Henry Pollard and Rod Bonello

    Citation: Trials 2009 10:6

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  11. Content type: Study protocol

    The Tehran Lipid and Glucose Study (TLGS) is a long term integrated community-based program for prevention of non-communicable disorders (NCD) by development of a healthy lifestyle and reduction of NCD risk fa...

    Authors: Fereidoun Azizi, Arash Ghanbarian, Amir Abbas Momenan, Farzad Hadaegh, Parvin Mirmiran, Mehdi Hedayati, Yadollah Mehrabi and Saleh Zahedi-Asl

    Citation: Trials 2009 10:5

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  12. Content type: Study protocol

    There is no recommendation to screen ferritin level in blood donors, even though several studies have noted the high prevalence of iron deficiency after blood donation, particularly among menstruating females....

    Authors: Baptiste Pedrazzini, Sophie Waldvogel, Jacques Cornuz, Paul Vaucher, Raphael Bize, Jean-Daniel Tissot, Alain Pecoud and Bernard Favrat

    Citation: Trials 2009 10:4

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  13. Content type: Commentary

    Flaws in research papers are common but it may require arduous detective work to unravel them. Checklists are helpful, but many inconsistencies will only be revealed through repeated cross-checks of every litt...

    Authors: Peter C Gøtzsche

    Citation: Trials 2009 10:2

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  14. Content type: Methodology

    Assessing the quality of included trials is a central part of a systematic review. Many check-list type of instruments for doing this exist. Using a trial of antibiotic treatment for acute otitis media, Burke ...

    Authors: Karim F Hirji

    Citation: Trials 2009 10:1

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  15. Content type: Study protocol

    Whiplash injuries are an important public health problem that is associated with significant disability and high health care utilization. Recent cohort studies suggest that physician care may be the most effec...

    Authors: Pierre Côté, J David Cassidy, Simon Carette, Eleanor Boyle, Heather M Shearer, Maja Stupar, Carlo Ammendolia, Gabrielle van der Velde, Jill A Hayden, Xiaoqing Yang, Maurits van Tulder and John W Frank

    Citation: Trials 2008 9:75

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  16. Content type: Study protocol

    Adhesive small intestine occlusion [ASIO] is an important cause of hospital admission placing a substantial burden on healthcare systems worldwide. Often times, ASIO is associated with significant morbidity an...

    Authors: Fausto Catena, Luca Ansaloni, Augusto Lauro, Giorgio Ercolani, Luigi D'Alessandro and Antonio Pinna

    Citation: Trials 2008 9:74

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  17. Content type: Study protocol

    Pelvic inflammatory disease (PID) is common and can lead to tubal factor infertility, ectopic pregnancy or chronic pelvic pain. Despite major UK government investment in the National Chlamydia Screening Progra...

    Authors: Pippa Oakeshott, Sally Kerry, Helen Atherton, Adamma Aghaizu, Sima Hay, David Taylor-Robinson, Ian Simms and Phillip Hay

    Citation: Trials 2008 9:73

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  18. Content type: Study protocol

    Experimental studies have shown that ultrasound contrast agents enhance the effectiveness of thrombolytic agents in the presence of ultrasound in vitro and in vivo. Recently, we have launched a clinical pilot stu...

    Authors: Jeroen Slikkerveer, Pieter A Dijkmans, Gertjan T Sieswerda, Pieter AFM Doevendans, Arie PJ van Dijk, Freek WA Verheugt, Thomas R Porter and Otto Kamp

    Citation: Trials 2008 9:72

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  19. Content type: Research

    Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2), however, its clinical efficacies on oral malodor have been evaluated only with organoleptic measurem...

    Authors: Kayoko Shinada, Masayuki Ueno, Chisato Konishi, Sachiko Takehara, Sayaka Yokoyama and Yoko Kawaguchi

    Citation: Trials 2008 9:71

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  20. Content type: Study protocol

    Hot flushes are the most frequent climacteric symptom and a major cause of suffering among menopausal women. The condition negatively influences many aspects of women's lives. To date, conventional hormone rep...

    Authors: Kun-Hyung Kim, Kyung-Won Kang, Hee-Jung Jung, Ji-Eun Park, So-Young Jung, Jun-Yong Choi and Sun-Mi Choi

    Citation: Trials 2008 9:70

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  21. Content type: Methodology

    Standards for reporting clinical trials have improved the transparency of patient-important research. The Consolidated Standards of Reporting Trials (CONSORT) published an extension to address noninferiority a...

    Authors: Oghenowede Eyawo, Chia-Wen Lee, Beth Rachlis and Edward J Mills

    Citation: Trials 2008 9:69

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  22. Content type: Study protocol

    Magnetic Resonance Imaging (MRI) of patients with implanted cardiac devices is currently considered hazardous due to potential for electromagnetic interference to the patient and pacemaker system. With approxi...

    Authors: Richard Sutton, Emanuel Kanal, Bruce L Wilkoff, David Bello, Roger Luechinger, Inge Jenniskens, Michael Hull and Torsten Sommer

    Citation: Trials 2008 9:68

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  23. Content type: Study protocol

    Panic disorder (PD) is a common, severe and persistent mental disorder, associated with a high degree of distress and occupational and social disability. A substantial proportion of the population experiences ...

    Authors: Peter Meulenbeek, Godelief Willemse, Filip Smit, Anton van Balkom, Philip Spinhoven and Pim Cuijpers

    Citation: Trials 2008 9:67

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  24. Content type: Study protocol

    Twenty to 30 percent of all transient ischaemic attacks and ischaemic strokes involve tissue supplied by the vertebrobasilar circulation. Atherosclerotic stenosis ≥ 50% in the vertebral artery accounts for ver...

    Authors: A Compter, HB van der Worp, WJ Schonewille, JA Vos, A Algra, TH Lo, WPThM Mali, FL Moll and LJ Kappelle

    Citation: Trials 2008 9:65

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  25. Content type: Letter

    There is wide recognition that pragmatic randomised trials are the best vehicle for economic evaluation. This is because trials provide the best chance of ensuring internal validity, not least through the rigo...

    Authors: Rhiannon T Edwards, Barry Hounsome, Pat Linck and Ian T Russell

    Citation: Trials 2008 9:64

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  26. Content type: Study protocol

    TB and HIV form a deadly synergy in much of the developing world, especially Africa. Interventions to reduce the impact of these diseases at community level are urgently needed. This paper presents the design ...

    Authors: Helen M Ayles, Charalambos Sismanidis, Nulda Beyers, Richard J Hayes and Peter Godfrey-Faussett

    Citation: Trials 2008 9:63

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  27. Content type: Study protocol

    Osteoporosis-related fractures are a significant public health concern. Interventions that increase detection and treatment of osteoporosis, as well as prevention of fractures and falls, are substantially unde...

    Authors: PM Ciaschini, SE Straus, LR Dolovich, RA Goeree, KM Leung, CR Woods, GM Zimmerman, SR Majumdar, S Spadafora, LA Fera and HN Lee

    Citation: Trials 2008 9:62

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  28. Content type: Study protocol

    A full-thickness macular hole (FTMH) is a common retinal condition associated with impaired vision. Randomised controlled trials (RCTs) have demonstrated that surgery, by means of pars plana vitrectomy and pos...

    Authors: Noemi Lois, Jennifer Burr, John Norrie, Luke Vale, Jonathan Cook and Alison McDonald

    Citation: Trials 2008 9:61

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  29. Content type: Study protocol

    Totally Implantable Access Ports (TIAP) are being extensively used world-wide and can be expected to gain further importance with the introduction of new neoadjuvant and adjuvant treatments in oncology. Two di...

    Authors: Philip Knebel, Lars Fischer, Eva Cremonese, Ruben Lopez-Benitez, Ulrike Stampfl, Boris Radeleff, Hans-Ulrich Kauczor, Markus W Büchler and Christoph M Seiler

    Citation: Trials 2008 9:60

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  30. Content type: Study protocol

    Following a stroke, 55–75% of patients experience upper limb problems in the longer term. Upper limb spasticity may cause pain, deformity and reduced function, affecting mood and independence. Botulinum toxin ...

    Authors: Helen Rodgers, Lisa Shaw, Christopher Price, Frederike van Wijck, Michael Barnes, Laura Graham, Gary Ford, Phil Shackley and Nick Steen

    Citation: Trials 2008 9:59

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  31. Content type: Study protocol

    A high perioperative inspiratory oxygen fraction may reduce the risk of surgical site infections, as bacterial eradication by neutrophils depends on wound oxygen tension. Two trials have shown that a high peri...

    Authors: Christian S Meyhoff, Jørn Wetterslev, Lars N Jorgensen, Steen W Henneberg, Inger Simonsen, Therese Pulawska, Line R Walker, Nina Skovgaard, Kim Heltø, Peter Gocht-Jensen, Palle S Carlsson, Henrik Rask, Sharaf Karim, Charlotte G Carlsen, Frank S Jensen and Lars S Rasmussen

    Citation: Trials 2008 9:58

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  32. Content type: Study protocol

    The effectiveness of using acupuncture to treat migraine is rarely and even suspectedly reported in the literature. In this article, we report the design and the protocol of a randomized controlled large-scale...

    Authors: Ying Li, Fanrong Liang, Shuguang Yu, Xuguang Liu, Yong Tang, Xuguang Yang, Xiaoping Tian, Jie Yan, Guojie Sun, Xiaorong Chang, Hui Zheng, Hongxing Zhang and Tingting Ma

    Citation: Trials 2008 9:57

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  33. Content type: Study protocol

    The management of neovascular age-related macular degeneration (nAMD) has been transformed by the introduction of agents delivered by intravitreal injection which block the action of vascular endothelial growt...

    Authors: Praveen J Patel, Catey Bunce and Adnan Tufail

    Citation: Trials 2008 9:56

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  34. Content type: Study protocol

    Renal failure is a frequent complication of multiple myeloma and when severe is associated with a greatly increased morbidity and mortality. The principal cause of severe renal failure is cast nephropathy, a d...

    Authors: Colin A Hutchison, Mark Cook, Nils Heyne, Katja Weisel, Lucinda Billingham, Arthur Bradwell and Paul Cockwell

    Citation: Trials 2008 9:55

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  35. Content type: Study protocol

    The MASS III Trial is a large project from a single institution, The Heart Institute of the University of Sao Paulo, Brazil (InCor), enrolling patients with coronary artery disease and preserved ventricular fu...

    Authors: Whady Hueb, Neuza H M Lopes, Bernard J Gersh, Cláudio C Castro, Felipe S Paulitsch, Sergio A Oliveira, Luis A Dallan, Alexandre C Hueb, Noedir A Stolf and José A F Ramires

    Citation: Trials 2008 9:52

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  36. Content type: Research

    Randomised controlled trials (RCTs) are perceived as the gold-standard method for evaluating healthcare interventions, and increasingly include quality of life (QoL) measures. The observed results are suscepti...

    Authors: Shona Fielding, Graeme Maclennan, Jonathan A Cook and Craig R Ramsay

    Citation: Trials 2008 9:51

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  37. Content type: Study protocol

    Point of care testing (PoCT) may be a useful adjunct in the management of chronic conditions in general practice (GP). The provision of pathology test results at the time of the consultation could lead to enha...

    Authors: Caroline Laurence, Angela Gialamas, Lisa Yelland, Tanya Bubner, Philip Ryan, Kristyn Willson, Briony Glastonbury, Janice Gill, Mark Shephard and Justin Beilby

    Citation: Trials 2008 9:50

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  38. Content type: Study protocol

    Peripheral arterial disease (PAD) is a common disease associated with a considerably increased risk of future cardiovascular events and most of these patients will die from coronary artery disease (CAD). Scree...

    Authors: Alexander M de Vos, Annemarieke Rutten, Hester J van de Zaag-Loonen, Michiel L Bots, Riksta Dikkers, Robert A Buiskool, Willem P Mali, Daniel D Lubbers, Arend Mosterd, Mathias Prokop, Benno J Rensing, Maarten J Cramer, H Wouter van Es, Frans L Moll, Eric D van de Pavoordt, Pieter A Doevendans…

    Citation: Trials 2008 9:49

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  39. Content type: Study protocol

    Depression frequently occurs in the elderly. Its cause is largely unknown, but several studies point to disturbances of biological rhythmicity. In both normal aging, and depression, the functioning of the supr...

    Authors: Ritsaert Lieverse, Marjan M A Nielen, Dick J Veltman, Bernard M J Uitdehaag, Eus J W van Someren, Jan H Smit and Witte J G Hoogendijk

    Citation: Trials 2008 9:48

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  40. Content type: Research

    Although interim analysis approaches in clinical trials are widely known, information on current practice of planned monitoring is still scarce. Reports of studies rarely include details on the strategies for ...

    Authors: Irene Floriani, Nicole Rotmensz, Elena Albertazzi, Valter Torri, Marisa De Rosa, Carlo Tomino and Fillipo de Braud

    Citation: Trials 2008 9:46

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  41. Content type: Research

    During clinical trials in emergency medicine, providing appropriate oral and written information to a patient is usually a challenge. There is little published information regarding patients' opinions and comp...

    Authors: Piotr Iwanowski, Andrzej Budaj, Anna Członkowska, Wojciech Wąsek, Beata Kozłowska-Boszko, Urszula Olędzka and Wojciech Masełbas

    Citation: Trials 2008 9:45

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