Volume 14 Supplement 1

2nd Clinical Trials Methodology Conference: Methodology Matters

Meeting abstracts

Publication of this supplement was funded by the 2nd Clinical Trials Methodology Conference.

2nd Clinical Trials Methodology Conference: Methodology Matters. Go to conference site.

Edinburgh, UK18-19 November 2013

Page 5 of 6

Statistical evaluation of surrogate endpoints: a systematic review

Authors: Hannah Ensor, Robert Lee, Cathie Sudlow and Christopher J Weir

Citation: Trials 2013 14(Suppl 1):P73

Content type: Poster presentation Published on: 29 November 2013
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An exploratory and confirmatory analysis of the oxford hip score: generation of subscales assessing self-reported function and pain

Authors: Kristina Harris, David Beard, Jill Dawson and Andrew Price

Citation: Trials 2013 14(Suppl 1):P74

Content type: Poster presentation Published on: 29 November 2013
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The challenges of using radiological ‘tumour response' as an outcome: lessons learned from neo-tango and artemis, two neo-adjuvant chemotherapy breast cancer trials

Authors: Louise Hiller, Janet Dunn, Anne-Laure Vallier, Clare Blenkinsop, Louise Grybowicz, Helen Higgins and Helena Earl

Citation: Trials 2013 14(Suppl 1):P75

Content type: Poster presentation Published on: 29 November 2013
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Overview of clinical outcome measures used in glaucoma randomised controlled trials (RCTS)

Authors: Rehab Ismail, Augusto Azuara-Blanco and Craig Ramsay

Citation: Trials 2013 14(Suppl 1):P76

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Core outcome set development: the effect of Delphi panel composition and feedback on prioritisation of outcomes

Authors: Rhiannon Macefield, Natalie Blencowe, Sara Brookes, Marc Jacobs, Mirjam Sprangers, Paula Williamson and Jane Blazeby

Citation: Trials 2013 14(Suppl 1):P77

Content type: Poster presentation Published on: 29 November 2013
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The consensus studysquamous cell carcinoma of the oropharynx: late phase clinical trials; core outcomes

Authors: Aoife Waters, Catrin Tudur-Smith, Bridget Young and Terry M Jones

Citation: Trials 2013 14(Suppl 1):P78

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Telephone calls to boost response rates in the collection of outcome data

Authors: Suzanne Breeman, Seonaidh Cotton, Alison McDonald, Gladys McPherson, Graeme MacLennan and Hanne Bruhn

Citation: Trials 2013 14(Suppl 1):P79

Content type: Poster presentation Published on: 29 November 2013
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What influences surgeons’ experience of surgical research?

Authors: Cushla Cooper, David Beard and Andrew Carr

Citation: Trials 2013 14(Suppl 1):P80

Content type: Poster presentation Published on: 29 November 2013
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We did it their way, flexible and robust patient recruitment to the IQuaD trial

Authors: Anne Duncan, Thomas Lamont, Jan Clarkson and Craig Ramsay

Citation: Trials 2013 14(Suppl 1):P81

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Factors affecting recruitment into depression trials: systematic review and meta-synthesis of qualitative evidence

Authors: Adwoa Hughes-Morley, Bridget Young and Peter Bower

Citation: Trials 2013 14(Suppl 1):P82

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Systematic review of interventions to increase recruitment and retention of black, minority and ethnic patients into randomised controlled trials

Authors: Gulnaz Iqbal, Janet Dunn and Margaret Thorogood

Citation: Trials 2013 14(Suppl 1):P83

Content type: Poster presentation Published on: 29 November 2013
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A review of recruitment of children to randomised clinical trials in the NIHR clinical research network portfolio

Authors: Geetinder Kaur, Rosalind Smyth and Paula Williamson

Citation: Trials 2013 14(Suppl 1):P84

Content type: Poster presentation Published on: 29 November 2013
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Survey of challenges and best practice strategies for participant recruitment to research projects in northern ireland

Authors: Lisa Maguire and Mike Clarke

Citation: Trials 2013 14(Suppl 1):P85

Content type: Poster presentation Published on: 29 November 2013
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It's all in whom you know (as well as what you know). Using network analysis and health professionals own knowledge for recruitment

Authors: Charlene McShane, Olinda Santin, Helen McAneney, Michael Donnelly, Jackie Quinn, Oonagh Sheehy, Liam Murray and Lesley Anderson

Citation: Trials 2013 14(Suppl 1):P86

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Challenges of recruiting elderly patients undergoing cardiac surgery - our experience of recruiting 2500 participants in just 30 months at a single centre

Authors: Zoe Plummer, Emma Hopkins, Lucy Culliford, Chris Rogers, Barnaby Reeves, Gavin Murphy, Veerle Verheyden and Andrew Mumford

Citation: Trials 2013 14(Suppl 1):P87

Content type: Poster presentation Published on: 29 November 2013
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Building the empire: a multi specialist, multi centre pragmatic trial

Authors: Rachel Rikunenko, Julie Dodds and Shakila Thangaratinam

Citation: Trials 2013 14(Suppl 1):P88

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Factors affecting the understanding and retention of the informed consent among participants at an antiretroviral clinical trial in a resource limited setting

Authors: Donald Salami

Citation: Trials 2013 14(Suppl 1):P89

Content type: Poster presentation Published on: 29 November 2013
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A multimedia intervention to enhance recruitment to clinical trials in primary care and community settings: process of development and evaluation

Authors: Peter Bower, David Collier, Sandra Eldridge, Jonathan Graffy, Anne Kennedy, Peter Knapp, Adwoa Hughes-Morley, Jo Rick, Chris Salisbury, Nicola Small, David Torgerson, Shaun Treweek and Peter Wallace

Citation: Trials 2013 14(Suppl 1):P90

Content type: Poster presentation Published on: 29 November 2013
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Electronic informed consent

Authors: Natasha Stevens

Citation: Trials 2013 14(Suppl 1):P91

Content type: Poster presentation Published on: 29 November 2013
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Do NIHR health technology assessment randomised clinical trials perform as well as expected?

Authors: Amanda Young, James Raftery, Louise Stanton and Andrew Cook

Citation: Trials 2013 14(Suppl 1):P92

Content type: Poster presentation Published on: 29 November 2013
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A mapping and gapping analysis of patient and public involvement in a clinical trials unit

Authors: Heather Bagley, Paula Williamson and Carrol Gamble

Citation: Trials 2013 14(Suppl 1):P93

Content type: Poster presentation Published on: 29 November 2013
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‘Things often get worse before they get better’: participants’ responses to the cessation of recruitment and trial treatment in a trial of a psychological therapy for people with personality disorder following a safety alert. (A missed opportunity for collaboration?)

Authors: Florence Day, Mary McMurran and Lelia Duley

Citation: Trials 2013 14(Suppl 1):P94

Content type: Poster presentation Published on: 29 November 2013
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Avoiding waste of research resource: cohort study of publication rate for funded studies from a major UK research funder

Authors: Sheila Turner, David Wright, Rebecca Maeso, Andrew Cook and Ruairidh Milne

Citation: Trials 2013 14(Suppl 1):P95

Content type: Poster presentation Published on: 29 November 2013
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Mixed methods in evaluating acupuncture and standard care for pregnant women with back pain: ease back

Authors: Bernadette Bartlam, Annette Bishop, Melanie Holden, Ismail Khaled, Christine Kettle and Nadine Foster

Citation: Trials 2013 14(Suppl 1):P96

Content type: Poster presentation Published on: 29 November 2013
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Qualitative enquiry supporting trials: the 'quest' to integrate qualitative methods in clinical trials

Authors: Clare Clement and Frances Rapport

Citation: Trials 2013 14(Suppl 1):P97

Content type: Poster presentation Published on: 29 November 2013
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Qualitative research within trials: developing a standard operating procedure for a clinical trials unit

Authors: Frances Rapport and Clare Clement

Citation: Trials 2013 14(Suppl 1):P98

Content type: Poster presentation Published on: 29 November 2013
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The role of clinical trials units in maximising qualitative research with RCTS

Authors: Cindy Cooper, Alicia O'Cathain, Danny Hind, Joy Adamson and Julia Lawton

Citation: Trials 2013 14(Suppl 1):P99

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A surgical feasibility trial from the surgeon's perspective: a qualitative study

Authors: Sharon McCann and Jonathan Cook

Citation: Trials 2013 14(Suppl 1):P100

Content type: Poster presentation Published on: 29 November 2013
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Using qualitative research within complex interventions: lessons from the podosa (prevention of diabetes and obesity in South Asians) trial

Authors: Zoe Morrison, Anne Douglas, Raj Bhopal and Aziz Sheikh

Citation: Trials 2013 14(Suppl 1):P101

Content type: Poster presentation Published on: 29 November 2013
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ELCID: early lung cancer identification and diagnosis - an embedded interview study to explore patient participation and recruitment

Authors: Hayley Prout, Richard Neal, Kirsty Roberts, Chris Hurt, Trevor Rogers, Willie Hamilton, Rhiannon Tudor Edwards, Angela Todd, David Parker, Emma Thomas Jones, Kerenza Hood, Gareth Griffiths, Allan Barham, Jim Fitzgibbon and Annmarie Nelson

Citation: Trials 2013 14(Suppl 1):P102

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Treatment for femoroacetabular impingement: a qualitative method for exploring equipoise amongst hip arthroscopy surgeons

Authors: Peter Wall, Alba Realpe, Damian Griffin, Rachel Hobson and Ann Adams

Citation: Trials 2013 14(Suppl 1):P103

Content type: Poster presentation Published on: 29 November 2013
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Practitioner views and experiences of deferred consent in paediatric and neonatal emergency care trials: the connect study

Authors: Kerry Woolfall, Lucy Frith, Carrol Gamble and Bridget Young

Citation: Trials 2013 14(Suppl 1):P104

Content type: Poster presentation Published on: 29 November 2013
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Analysis of longitudinal oncology quality of life (QoL) data - are we getting it right?

Authors: Kim Cocks, Puvan Tharmanathan and Adam Smith

Citation: Trials 2013 14(Suppl 1):P105

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Testing the equivalence of survival distributions using PP- and PPP-plots

Authors: Trevor Cox

Citation: Trials 2013 14(Suppl 1):P106

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A new approach to dealing with the analysis of cutpoints in time to event analyses, designed to correct for the over-inflation both of significance levels and of survival differences

Authors: Walter Gregory and Susan Burchill

Citation: Trials 2013 14(Suppl 1):P107

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Can follow-up reminders from postal questionnaires help determine the mechanism of missing data in trials?

Authors: Ivana Holloway, Amanda Farrin and Anne Forster

Citation: Trials 2013 14(Suppl 1):P108

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Adjusting for informative missing outcome data in clinical trials with longitudinal study designs

Authors: Ruwanthi Kolamunnage-Dona, Colin Powel and Paula Williamson

Citation: Trials 2013 14(Suppl 1):P109

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Evaluation of bias and precision in methods of analysis for pragmatic trials with missing outcome data: a simulation study

Authors: Royes Joseph, Julius Sim, Reuben Ogollah and Martyn Lewis

Citation: Trials 2013 14(Suppl 1):P110

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Information-theoretic model averaging: a useful method for modelling exploratory secondary endpoints in clinical trials

Authors: Daniel Lythgoe

Citation: Trials 2013 14(Suppl 1):P111

Content type: Poster presentation Published on: 29 November 2013
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Mediated effect of cognitive behavioural therapy on depression outcomes

Authors: Lang'o Odondi, Glyn Lewis, Willem Kuyken, Chris Metcalfe and Nicola Wiles

Citation: Trials 2013 14(Suppl 1):P112

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Applying missing data methods to routine data: a prospective, population-based register of people with diabetes

Authors: Stephanie Read, Sarah Wild and Steff Lewis

Citation: Trials 2013 14(Suppl 1):P113

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Does stimulus predict the best candidates for deep brain stimulation for PD?

Authors: Caroline Rick, Smitaa Patel, Natalie Ives, Francis Dowling, Jane Daniels, Steven Gill, Crispin Jenkinson, Rosalind Mitchell, Hardev Pall, Niall Quinn, Carl Clarke, TRK Varma, Keith Wheatley and Adrian Williams

Citation: Trials 2013 14(Suppl 1):P114

Content type: Poster presentation Published on: 29 November 2013
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Challenges in the development of prognostic models utilising clinical trials data

Authors: Kym Snell, Lucinda Billingham, Deborah Stocken and Richard Riley

Citation: Trials 2013 14(Suppl 1):P115

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Statistical modelling of biomarkers incorporating non-proportional effects for survival data

Authors: Jacqueline Stephen, Gordon Murray, John Bartlett and David Cameron

Citation: Trials 2013 14(Suppl 1):P116

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Predicting risks and benefits of treatment with aspirin in the acute stage of ischaemic stroke: an analysis of 3 large randomised controlled trials

Authors: Douglas Thompson, Gordon Murray and William Whiteley

Citation: Trials 2013 14(Suppl 1):P117

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Clinical course of untreated cerebral cavernous malformations: individual patient data meta-analysis

Authors: Margaret Horne, Kelly Flemming, I-Chang Su, Christian Stapf, Robert Brown Jr, Teresa Christianson, Ronit Agid, Karel terBrugge, Robert Willinsky, Susanne Maxwell, Gordon Murray and Rustam Al-Shahi Salman

Citation: Trials 2013 14(Suppl 1):P118

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A mixed treatment comparison of Erlotinib vs. placebo and Erlotinib vs. Geftinib using Bayesian approaches

Authors: Iftekhar Khan, Gianluca Baio and Saira Ahmed

Citation: Trials 2013 14(Suppl 1):P119

Content type: Poster presentation Published on: 29 November 2013
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Practical methods for ordinal data meta-analysis in stroke

Authors: Ashma Krishan, James Weir, Gordon Murray, Brenda Thomas, Peter Sandercock and Steff Lewis

Citation: Trials 2013 14(Suppl 1):P120

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Compliance of randomised controlled trials in trauma surgery with the consort statement: a systematic review

Authors: Seon-Young Lee, Penelope Teoh, Christian Camm and Riaz Agha

Citation: Trials 2013 14(Suppl 1):P121

Content type: Poster presentation Published on: 29 November 2013
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Inadequate reporting of sample size calculations in cluster randomised trials: a review

Authors: Clare Rutterford, Monica Taljaard, Stephanie Dixon, Andrew Copas and Sandra Eldridge

Citation: Trials 2013 14(Suppl 1):P122

Content type: Poster presentation Published on: 29 November 2013
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