| Study period | |||||
---|---|---|---|---|---|---|
 | Enrolment | Allocation | Post-allocation | Close-out | ||
Timepoint | − 14 days | Day 0 | Day 1 | Day 14 | Day 30 | Day 90 |
Enrolment: | ||||||
 Eligibility screen | X |  |  |  |  |  |
 Informed consent | X |  |  |  |  |  |
Interventions: | ||||||
 PFM |  | X |  |  |  |  |
 Sham-control |  | X |  |  |  |  |
Assessments: | ||||||
 Office BP measurement | X |  | X | X | X | X |
 24-h ambulatory BP measurement | X |  | X |  | X | X |
 History of diseases | X |  |  |  |  |  |
 Physical examinations | X |  |  |  | X | X |
 Drugs use record | X |  |  | X | X | X |
 Antihypertensive drugs concentration tests | X |  |  |  | X | X |
 Blood routine | X |  | X |  | X | X |
 Biochemical test | X |  | X |  | X | X |
 C-reactive protein | X |  | X |  |  |  |
 Biomarkers of acute renal injury | X |  | X |  |  |  |
 ECG | X |  | X |  | X | X |
 Renal and renal artery ultrasound | X |  | X |  | X | X |
 Carotid ultrasound | X |  | X |  | X | X |
 Cardiac ultrasound | X |  |  |  |  |  |
 MR imaging of perirenal fat | X |  |  |  | X | X |
 Functional MR imaging of hypothalamus | X |  |  |  | X | X |