Table 2 Biomarker analyses
Compartment | Biomarker | Endpoint |
|---|---|---|
Blood | ➢ PR3 ANCA (ELISA) ➢ Lymphocyte immunophenotyping (flow cytometry) ➢ B cell receptor clonality, B cell and T cell functional assays, and whole blood transcriptomic analysis ➢ BAFF protein, BAFF-belimumab complex and cytokines | Primary Secondary Exploratory Exploratory |
Urine | ➢Lymphocyte immunophenotyping (flow cytometry) ➢Proteome analysis | Exploratory Exploratory |
Tissue biopsies (subset of patients only) | ➢Lymphocyte immunophenotyping (flow cytometry) ➢Single cell RNA sequencing | Exploratory Exploratory |