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Fig. 1 | Trials

Fig. 1

From: DEPROMP Trial: the additive value of PSMA-PET/CT-guided biopsy for prostate cancer management in biopsy naïve men—study protocol for a randomized trial

Fig. 1

Annotation of suspicious lesions on imaging. AC Concordant positive findings of clinically significant prostate cancer (csPCA) in the peripheral zone of the right prostate lobe on multiparametric magnetic resonance imaging (MRI) and gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA-PET/CT). In the DEPROMP Trial, uro-radiologists (A, B) and nuclear medicine physicians (C) annotate defined suspicious lesions in imaging layers to enable effective and clear interdisciplinary communication before targeted biopsy (TB) as demonstrated in exemplary fashion. An example of a false-negative MRI with true-positive PSMA-PET/CT in the posterior transitional zone of the left prostate lobe is shown in series DF. The PSMA-PET/CT-guided TB detected a solitary, Gleason 3 + 4 PCA. In both cases, radical prostatectomy confirmed the risk stratification based on biopsy yields

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