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Table 2 Schedule of the major study events

From: The efficacy of nalmefene on anesthetic recovery of patients: a study protocol for a multicenter randomized controlled trial

 

Screening period

Intervention and observation period

 

-7 ~ -1 day

Preoperative

Intraoperative

Sugery ended

Duration of stay in PACU

24 h postoperatively

Informed consent

X

     

Medical history

X

     

Physical examination

X

     

Demographics

X

     

ECG

X

    

X

Blood cell testa

X

    

X

Liver and kidney functionb

X

     

Inclusion /exclusion criteria

 

X

    

Randomization

 

X

    

Intraoperative narcotic analgesics

  

X

   

Non-steroidal antiinflammatory drugs(NSAIDs)

  

X

   

Trial drug

   

X

  

Neostigmine

    

X

 

Atropine

    

X

 

Electronic intravenous analgesia pump

   

X

X

X

Extubation time

    

X

 

Aldrete score

    

X

 

VAS score

    

X

X

RASS score

    

X

 

Montreal orientation score

    

X

 

Remedial analgesic sufentanilc

    

X

 

PONV

    

X

X

Pruritus

    

X

X

Combination medicationd

X

X

X

X

X

X

Adverse events

X

X

X

X

X

X

  1. Remarks: Collect the latest laboratory and auxiliary examination results within 7 days before the baseline
  2. aBlood test: red blood cells, white blood cells, platelet counts, hemoglobin
  3. bLiver and kidney function: alanine aminotransferase, aspartate aminotransferase, creatinine, blood urea nitrogen
  4. cRemedial analgesic: sufentanil
  5. dCombination medication: Medication only recorded at the time of adverse event