Table 1 Time schedule for the trial

Timepoint

0 h

6 h

12 h

24 h

36 h

48 h

72 h

Days 90 and 180

Enrolment

 Eligibility screen

x

 Informed consent

Trial guardian and next of kin

Patient as soon as possible

 Randomization

x

Interventions

 Infusion of study drug

x

Assessments

 Biochemistry^a

x

x

x

x

x

x

x

 Biobank samples

x

x

x

x

 ECG

x

x

x

x

x

x

x

 Swan-Ganz-based measurements

x

x

x

x

x

x

x

 Echocardiography

Day 1

Before discharge

 ABG and VBG^b

x

x

x

x

x

x

x

 SOFA score

x

x

x

 CPC and mRS score

x

 MoCA score

Only day 90