Table 2 Spirit figure: schedule of enrollment, interventions, and assessment

 Eligibility Criteria

x

 Informed Consent

x¹

x²

 Randomization

x

 Study medication

x

x

x

x

x

x

x

x

x

x

x

 Other treatments

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

 Antiviral treatment ***

(x)

(x)

(x)

(x)

(x)

(x)

(x)

x

x

x

x

x

x

x

x

  Physical. examination*

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

  Visual tests **

x

x

x

x

x

x

x

x

x

x

x

x

x

x

  Neuropathy tests **

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

  Functional tests **

x

x

x

x

x

x

x

x

x

x

x

x

x

x

  Cognitive tests **

x

  Depression tests **

x

  Brain imaging

(x³)

  Chest X-ray

x

  HIV serology

x

  Full blood count ^†

x

x

x

x

x

x

x

x

x

x

x

x*

x*

  Plasma electrolytes ^††

x

x

x

x

x

x

x

x

x

x

x

x*

  Creatininemia

x

x

x

x

x

x

x

x

x

x

x

x*

  Glycemia

x

x

x

x

x

x

x

x

x

x

x

  Albuminemia

x

x

x

  ALT, Bilirubin (T/U)

x

x

x

x

x

x

x

x

x

x

x

x*

x*

  Cryptococcus Ag *

x*

  HIV-1 RNA Viral load *

x*

x*

x*

x*

x*

  CD4 cell count *

x*

x*

x*

x*

  PK rifampicin/linezolid

x

x

  Rapid Pregnancy test

x

  Urine LAM *

x*

  TBM tests ^‡

x

(x¹)

x

(x²)

  Bacterial tests ^¥

x

  Cryptococcus Ag *

x*

  PK rifampicin/linezolid

x

x

  Sputum TB tests

x

(x³)