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Table 1 Doses and number of tablets of anti-TB drugs across the weight range

From: Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Regimen

Weight range (kg)

30–39

40–49

50–59

60–70

>70

Standard WHO TBM treatment

R dose calculated (Target 10 mg/kg)

350 mg

450 mg

550 mg

650 mg

>700 mg

Fixed-dose combination R150 H75 Z400 E275

2 tablets

3 tablets

4 tablets

4 tablets

5 tablets

R dose dispensed

300 mg

450 mg

600 mg

600 mg

750 mg

Intensified TBM treatment

R dose calculated (Target 35 mg/kg)

1225 mg

1575 mg

1925 mg

2380 mg

>2450 mg

Fixed-dose combination R150 H75 Z400 E275

2 tablets

3 tablets

4 tablets

4 tablets

5 tablets

LZD 600

2 tabletsa

2 tabletsa

2 tabletsa

2 tabletsa

2 tabletsa

Additional R300

3 tablets

4 tablets

5 tablets

6 tablets

6 tablets

R dose dispensed

1200 mg

1650 mg

2100 mg

2400 mg

2550 mg

  1. a2 tablets from week 1 to week 4 then 1 tablet from week 5 to week 8