Preoperative oral diazepam for intraoperative blood pressure stabilisation in hypertensive patients undergoing vitrectomy under retrobulbar nerve block anaesthesia: study protocol for a randomised controlled trial

Table 1 Standard Protocol Items: Recommendations for Intervention Trials (SPIRIT)

Timepoint	Study period
	Enrolment	Allocation	Perioperation	Post-surgery	Follow-up
	Recruitment (1 day before operation)	Randomisation (1h before operation)	Before and after anaesthesia, every 5 min from the start of operation	1 h after operation	Within one month after operation
Enrolment:
Eligibility screen	×
Informed consent	×
Randomisation and allocation		×
Interventions:
Diazepam group (oral diazepam 2.5 mg before operation)		×
Placebo group (oral placebo before operation)		×
Assessments:
Blood pressure	×	×	×	×	×
Heart rate	×	×	×	×	×
Adverse reactions		×	×	×	×

ISSN: 1745-6215