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Table 3 Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) figure

From: A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trial

  1. t1 28 days after allocation, t2a week 6 follow-up, t3b week 12 follow-up
  2. cChanges in liver disease severity, quality of life, and cost-effectiveness compared to standard care
  3. d(a) Source of referral, (b) re-enrolment after unplanned hospitalisation, (c) COVID-19, and (d) hepatic decompensation without ACLF