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Table 2 MRI scoring methods

From: Efficacy and safety of guselkumab in biologic-naïve patients with active axial psoriatic arthritis: study protocol for STAR, a phase 4, randomized, double-blinded, placebo-controlled trial

Disease activity assessed

Methodology

Spondyloarthritis Research Consortium of Canada (SPARCC)

 Inflammation in SI joints [26]

Each SI joint divided into 4 quadrants and scored for bone marrow edema in each of 6 consecutive semicoronal slices, with additional points for signal intensity and depth

 Inflammation in spine [28]

Each discovertebral unit divided into 4 quadrants and scored in each of 3 slices for presence of bone marrow edema in each quadrant, with additional points for signal intensity and depth

 

Total score: 0–414

Canada-Denmark (CAN-DEN)

 Inflammation and damage in spine [29]

The system is a detailed anatomy-based evaluation of inflammatory and structural lesions in vertebral bodies and posterior elements of the spine. Features assessed: inflammation (0–614), fat (0–510), bone erosion (0–208), new bone formation (0–460)

Outcome Measures in Rheumatology (OMERACT) Psoriatic Arthritis MRI Scoring System (PsAMRIS)a

 Inflammation and destructive changes in peripheral joints [30]

Features assessed (score range):

• Synovitis (hands: 0–42; feet: 0–18)

• Flexor tenosynovitis (hands: 0–42; feet: 0–18)

• Periarticular inflammation (hands: 0–28; feet: 0–12)

• Bone marrow edema (hands: 0–84; feet: 0–36)

• Bone erosion (hands: 0–280; feet: 0–120)

• Bone proliferation (hands: 0–14; feet: 0–6)

  1. SI sacroiliac
  2. aExploratory analysis in a subset of patients (n = 50 in each group)