Table 1 Overview of participant timeline. CRP C-reactive protein, EQ-5D-5L questionnaire assessing quality of life, GDA global disease activity, HAQ health assessment questionnaire, PASS patient acceptable symptom state, RA rheumatoid arthritis, SJC swollen joint count, TJC tender joint count, VAS visual analog scale 0–100 mm

Month

 − 3 to 0

0

3

6

9

12

15

18

…

Informed consent

X

Eligibility criteria

X

Demographic data

X

Medical history

X

Anti-rheumatic treatment

X

X

X

X

X

X

X

X

X

Smoking and alcohol use

X

Height, Weight

X

Randomization

X

Clinical disease parameters

 28TJC and 28SJC

X

X

X

X

X

X

X

X

X

 Provider VAS GDA

X

X

X

X

X

X

X

X

 Patient VAS GDA

X

X

X

X

X

X

X

X

X

Questionnaires

 HAQ-DI

X

X

X

X

X

X

X

 EQ-5D-5L

X

X

X

X

X

X

X

 RA flare questionnaire^a

X

X

X

X

X

X

X

X*

 PASS

X

X

X

X

X

X

X

X*

 Likert transition question

X

X

X

X

X

X

X

X*

 Health care utilization and work participation

X

X

X

X

X

X

X

 Patients satisfaction with care (Dutch SAPS)

X

 Physician satisfaction with care (VAS)

X

Laboratory assessments

 CRP

X

X

X

X

X

X

X

X

Safety/adverse events

 (Serious) Adverse events

X

X

X

X

X

X

X

X