Ventilator-associated pneumonia prevention in the Intensive care unit using Postpyloric tube feeding in China (VIP study): study protocol for a randomized controlled trial

Table 2 Trial schedule of the VIP study

Timepoint	Baseline	^aInterventions									Termination
Timepoint	^bD0	D1	D2, ^cN1	D..., N...	D4	D5	D6	D7	D8, N7	D…	D28
Eligibility screening	×
Informed consent obtaining	×
Randomization	×
Medical history collection	×
Population data collection	×
Baseline data collection	×
Evaluation of major adverse tube-associated events (MATE)		×	×
Evaluation of ^dEN related adverse events			×	×	×	×	×	×	×	×	×
Evaluation of serious adverse events		×	×	×	×	×	×	×	×	×	×
VAP episode		×	×	×	×	×	×	×	×	×	×
Microorganisms causing VAP		×	×	×	×	×	×	×	×	×	×
Duration of mechanical ventilation		×	×	×	×	×	×	×	×	×	×
SOFA score		×	×	×	×	×	×	×	×	×	×
CPIS score		×	×	×	×	×	×	×	×	×	×
Serum albumin and C-reactive protein		×	×						×
ICU-acquired infections (bloodstream, urinary tract, catheter-related, and other infections)		×	×	×	×	×	×	×	×	×	×
Day calorie target		×	×	×	×	×	×	×	×	×
Day actual calorie		×	×	×	×	×	×	×	×	×
Day calorie deficit		×	×	×	×	×	×	×
Ventilator free		×	×	×	×	×	×	×	×	×	×
Transfer out of ICU		×	×	×	×	×	×	×	×	×	×
ICU survival		×	×	×	×	×	×	×	×	×	×
Discharge		×	×	×	×	×	×	×	×	×	×
Hospital survival		×	×	×	×	×	×	×	×	×	×
28-day survival											×

Eligibility screening includes diagnosis, inclusion/exclusion criteria, urine pregnancy test for female, demographics, medical history, and physical examination
CPIS Clinical Pulmonary Infection Score, EN Eenteral nutrition, MATE Major adverse tube-associated event, SOFA Sequential Organ Failure Assessment score
^aIntervention means postpyloric tube feeding
^bD means day from enrollment
^cN means day from enteral nutrion
^dEN-related adverse events include abdominal distension, gastric retention, vomiting, diarrhea, and aspiration of gastric contents

ISSN: 1745-6215