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Table 1 Active Collaboratory demonstration projects at the outset of the pandemic

From: The impact of COVID-19 on pragmatic clinical trials: lessons learned from the NIH Health Care Systems Research Collaboratory

Acronym (ClinicalTrials.gov identifier)

Trial name

Therapeutic area

Implementation phase

 ACP PEACE (NCT03609177)

Improving Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly

Cancer

 EMBED (NCT03658642)

Pragmatic Trial of User-Centered Clinical Decision Support to Implement Emergency Department-Initiated Buprenorphine for Opioid Use Disorder

Opioid use disorder

 GGC4H (NCT04040153)

Guiding Good Choices for Health: Testing Feasibility and Effectiveness of Universal Parent-Focused Prevention in Three Healthcare Systems

Adolescent behavioral health

 HiLo (NCT04095039)

Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis

Hemodialysis

 ICD-Pieces (NCT02587936)

Improving Chronic Disease Management with Pieces

Chronic kidney disease, diabetes and hypertension

 Nudge (NCT03973931)

Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications

Cardiovascular disease

 PRIM-ER (NCT03424109)

Primary Palliative Care for Emergency Medicine

Palliative care

Pilot phase

 BackInAction (NCT04982315)

Pragmatic Trial of Acupuncture for Chronic Low Back Pain in Older Adults

Chronic pain

 FM-TIPS (NCT04683042)

Fibromyalgia TENS in Physical Therapy Study

Fibromyalgia/chronic pain

 NOHARM (NCT04570371)

Nonpharmacologic Options in Postoperative Hospital-based and Rehabilitation Pain Management

Post-surgical pain

 OPTIMUM (NCT04129450)

Group-based Mindfulness for Patients with Chronic Low Back Pain in the Primary Care Setting

Chronic pain

Completed enrollment

 PROVEN (NCT02612688)

Pragmatic Trial of Video Education in Nursing Homes

Advanced care planning

 SPOT (NCT02326883)

Suicide Prevention Outreach Trial

Behavioral health

 TSOS (NCT02655354)

A Policy-Relevant U.S. Trauma Care System Pragmatic Trial for PTSD and Comorbidity (Trauma Survivors Outcomes and Support)

Behavioral health