Effectiveness of a clinical decision support system for hypertension management in primary care: study protocol for a pragmatic cluster-randomized controlled trial

Table 1 Inclusion and exclusion criteria of participants for LIGHT and LIGHT-ACD trials

Criteria	LIGHT	LIGHT-ACD
Inclusion	Residents aged ≥18 years registered for hypertension treatment at primary care sites	Participants from intervention sites of LIGHT study with systolic blood pressure ≥140 mmHg at the screening visit
Inclusion	Taking 0–2 classes of antihypertensive medications	Not taking antihypertensive medication or taking only one which was not beta-blocker
Exclusion	History of coronary heart disease^a, heart failure, and chronic kidney disease	Known/diagnosed diabetes mellitus
	Intolerance to 2 or more classes of antihypertensive medications	Intolerance to 1 or more classes of antihypertensive medications
	Secondary hypertension (physician-diagnosed)	Home blood pressure (if available) below 135/85 mmHg
	Systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg at the screening visit
	Serious medical conditions (e.g., malignant cancer and hepatic dysfunction)
	Currently in an acute episode of disease
	Currently pregnant or breastfeeding, or planning a pregnant or breastfeeding during the study
	Cognitive or communication disorders

^a Including angina, myocardial infarction, coronary artery bypass grafting, percutaneous coronary intervention, >50% stenosis of coronary artery, or positive stress test

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