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Table 1 Schedule of study activities

From: Tuberculosis screening improves preventive therapy uptake (TB SCRIPT) trial among people living with HIV in Uganda: a study protocol of an individual randomized controlled trial

Timepoint

Entry

Weeks

Months

0

2

4

6

8

3

4

5

6

12

18

24

Enrollment

 Eligibility screen

           

 Informed consent

           

 Randomization

           

Study activities

 Baseline TB screening by trial arm

           

 Urine pregnancy testing

           

 Capillary blood β-hCG testing

           

 Banking of serum/plasma and urine

    

  

Screen-negatives

 TPT eligibility assessment

           

 Liver enzyme testing (if eligible for TPT)

           

 TPT initiation

 

          

 TPT adherence monitoring

   

 

      

Screen-positives

 Urine LAM

           

 Xpert Ultra (if LAM-negative or at risk for DR TB)

           

 TB treatment initiation

 

          

 TB treatment adherence monitoring

     

  

   

Final TB status assessment

 Xpert Ultra

           

 Liquid mycobacterial culture

           

 Drug susceptibility testing

           

Routine clinic activities

 CD4 count

           

 Blood chemistry

           

 Complete blood count

           

 ART initiation

           

 Routine clinic follow-up visit

 

 

 

  

 HIV viral load

        

Participants initiated on anti-TB therapy

 AE monitoring

 

 

   

 TB treatment adherence monitoring

 

 

   

 Medication refills