|
Study period
|
Pre-treatment
|
Treatment
|
Follow-up
|
|---|
|
Timepoint (weeks)
|
<− 2
|
0
|
6
|
12
|
24
|
36
|
|
Enrollment
|
|
Informed consent
|
X
| | | | | |
|
Eligibility assessment
|
X
| | | | | |
|
Baseline variables
| |
X
| | | | |
|
Allocation
| |
X
| | | | |
|
Interventions
|
|
CCFES
| |
◊------
|
-------------
|
------◊
| | |
|
cNMES
| |
◊------
|
-------------
|
------◊
| | |
|
TOT
| |
◊------
|
-------------
|
------◊
| | |
|
Assessments
|
|
End of Treatment Questionnaire
| | | |
X
| | |
|
SIS – Hand Section
| |
X
| |
X
| |
X
|
|
Neuro-QOL UE Function
| |
X
| |
X
| |
X
|
|
Modified Ashworth Scale
| |
X
|
X
|
X
|
X
|
X
|
|
UEFM
| |
X
|
X
|
X
|
X
|
X
|
|
BBT
| |
X
|
X
|
X
|
X
|
X
|
|
SULCS
| |
X
|
X
|
X
|
X
|
X
|
|
ARAT
| |
X
|
X
|
X
|
X
|
X
|
|
MEP excitability
| |
X
| |
X
| |
X
|
|
Ipsilateral MEP excitability
| |
X
| |
X
| |
X
|
|
Interhemispheric inhibition
| |
X
| |
X
| |
X
|
- CCFES contralaterally controlled functional electrical stimulation, cNMES cyclic neuromuscular electrical stimulation, TOT task-oriented-training, SIS stroke impact scale, QOL quality of life, UE upper extremity, UEFM upper extremity Fugl-Meyer assessment, BBT box and blocks test, SULCS stroke upper limb capacity scale, ARAT action research arm test, MEP motor evoked potential
