Effect of GOAL-Directed ANalgesia using ANI (Analgesia/Nociception Index) during general anesthesia on immediate postoperative pain and intraoperative hemodynamics in adult patients (GOALDAN study): a study protocol for randomized, controlled, multicenter trial

Table 1 Participant timeline

Time point**	Study period
	Enrollment	Allocation	Post-allocation				Close-out
	D-1	D0	D0	D1	D7	D28	D28
Enrollment
Eligibility screen	X
Informed consent	X
Inclusion and non-inclusion criteria	X
Allocation		X
Interventions
Control group			X				X
Experimental group			X				X
Assessments
Clinical data			X
Pain intensity (NRS scale)			X	X		X	X
Dose of analgesics			X	X
Postoperative complications (POMS)				X	X
Vital status						X	X

ISSN: 1745-6215