Table 1 Schedule of assessments

Signed informed consent

X

Inclusion/exclusion

X

X

X

Randomisation

X

IWRS

X

X

X

Demography

X

MEHI

X

Medical/surgical history/history BPD

X

Current medication

X

X

X

X

X

X

X

Vital signs—HR, BP, and RR

X

X

X

X

X

X

X

X

X

SCID-RV

X

HDRS

X

X

X

X

X

X

X

YMRS

X

X

X

X

X

X

X

AUDIT

X

Pregnancy discussion

X

X

X

X

X

Contraception advice

X

X

X

X

X

Serum pregnancy test^Δ

X

Pregnancy urine dipstick^Δ

X

X

X

X

U&Es, LFTs, TFTs°

X

X

Fagerstrom

X

CGI-S

X

X

X

X

X

X

CGI-I

X

X

X

X

X

VAS

X

X

X

X

X

X

X

X

MADRS

X

X

X

X

X

X

GAF

X

X

X

X

ECG

X

Height (cm) and weight (kg)

X

IV cannulation

X

X

X

X

Infusion administration

X

X

X

X

Adverse events

X

X

X

X

X

X

X

X

X

X

X

X

X

X

Cannulation site check

X

X

X

X

X

X

X

X

POMS (optional)

X

X

X

X

X

X

X

X

X

X

CANTAB ^b (optional)

X

X

X

WAIS ^a (optional)

X^a

X^a

X^a

X^a

X^a

X^a

NEO-PI-FFI ^a (optional)

X^a

X^a

X^a

X^a

X^a

X^a

PRISE (optional)

X

X

X

X

Subjective assessment

X