The effect of a loading dose of meropenem on outcomes of patients with sepsis treated by continuous renal replacement: study protocol for a randomized controlled trial

Table 1 Schedule of subject enrollment, intervention strategies, and evaluation

	STUDY PERIOD
		Day after randomization
Time point	-t1	0	1	2	3	4	5	6	7	8	9	10	11	12	13	14	EOT/E
Enrolment: (May 2020-May 2021)
Eligibility screen	×
Informed consent	×
Allocation		×
APACHE II Score		×
Intervention: (May 2020-May 2021)
Intervention group			×	×	×	×	×	×	×	×	×	×	×	×	×	×
Control group			×	×	×	×	×	×	×	×	×	×	×	×	×	×
Assessments: (May 2020 -Dec 2021)
PK/PD target			×	×
Clinical response/ Microbiological outcomes					×		×		×			×				×	×
SOFA-score		×	×	×	×	×	×	×	×	×	×	×	×	×	×	×	×
CRP, WBC, PCT		×			×		×		×			×				×	×

EOT End of therapy, E Discharge from ICU, SOFA Sequential Organ Failure Assessment, CRP C-reactive protein, WBC White blood cell, PCT Procalcitonin

ISSN: 1745-6215