PolyMyalgia Rheumatica treatment with Methotrexate in Optimal Dose in an Early disease phase (PMR MODE): study protocol for a multicenter double-blind placebo controlled trial

Table 1 Treatment set-up for initial responders without relapse

	Time in weeks	0	4	8	12	16	20	24	28	32	36	40	44	48	52
MTX group	Prednisolone (mg/day)	15	12.5	10	7.5	5	2.5	0	0	0	0	0	0	0	0
	MTX (mg/week)	15	25	25	25	25	25	25	25	25	25	25	25	25	25
	Folic acid (mg/week)	10	10	10	10	10	10	10	10	10	10	10	10	10	10
Placebo group	Prednisolone (mg/day)	15	12.5	10	7.5	5	2.5	0	0	0	0	0	0	0	0
	MTX (mg/week)	0	0	0	0	0	0	0	0	0	0	0	0	0	0
	Folic acid (mg/week)	10	10	10	10	10	10	10	10	10	10	10	10	10	10

ISSN: 1745-6215