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Table 5 Power calculations

From: Tolvaptan versus fluid restriction in acutely hospitalised patients with moderate-profound hyponatraemia (TVFR-HypoNa): design and implementation of an open-label randomised trial

Difference between arms

Number per group

+ 30% to allow for drop-outs and autocorrection

Total sample size

2 mmol/L

64

83

166

3 mmol/L

43

56

112

4 mmol/L

26

34

68

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Trials

ISSN: 1745-6215