Table 2 Thresholds for intervention with intravenous dextrose 5% in the context of sodium rise following tolvaptan dose
Rise in serum sodium | Time post-tolvaptan | Action |
|---|---|---|
> 6 mmol/L | Within 6 h | Commence IV dextrose 5% at rate equivalent to urine output, continue to monitor frequently and cease when sodium back within target range |
> 8 mmol/L | Within 12 h | |
> 10 mmol/L | Within 24 h | Aim for re-lowering with bolus hypotonic fluid |