Primary composite endpoint | Secondary endpoint |
---|---|
1.) Unplanned re-hospitalization | 1.) Death |
2.) Death | 2.) Unplanned re-hospitalization |
 | 3.) Any infection and differentiated by site of infection (SBP, pneumonia, urinary tract infection, blood stream infection, Clostridium difficile-associated enterocolitis, Norovirus infection, SARS-CoV-2 infection, others) |
 | 4.) Acute hepatic decompensation and ACLF |
 | 5.) Upper or lower gastrointestinal bleeding event |
 | Safety endpoint: Evidence based re-therapy with PPI due to the occurrence of any the following conditions: |
 | 1.) Peptic ulcer diagnosed by EGD |
 | 2.) Reflux esophagitis LA grade C or D diagnosed by EGD |
 | 3.) Severe hemorrhagic gastritis diagnosed by EGD and histology |
 | 4.) Mallory-Weiss syndrome diagnosed by EGD |