Weight banda | Numbers of tablets |
---|
Intensive phase RHZ 75/50/150 | Intensive phase Ethambutol 100b | Continuation phase RH 75/50 |
---|
4–7 kg | 1 | 1 | 1 |
8–11 kg | 2 | 2 | 2 |
12–15 kg | 3 | 3 | 3 |
16–24 kg | 4 | 4 | 4 |
25+ kg | Adult dosages recommended |
- a Infants below 4 kg will receive half FDC and half ethambutol pill. The safety and efficacy of this formulation have not been assessed in large studies in infants, but equivalent liquid formulations are used routinely. A PK sub-study (PK 4) to investigate the relationships between age, peak concentrations of TB agents, and efficacy/toxicity to guide the treatment with FDC in infants weighing lower than 4 kg will be done. As soon as a result arises, the dosage will be updated if necessary
- bEthambutol should be added in the intensive phase for all recruited children following WHO recommendation as they are HIV-infected