Table 1 Outcome evaluation time points

Visit date

X

X

X

X

X

X

X

Inclusion/exclusion criteria

X

Informed consent

X

Demographic data

X

Vital signs and physical examination

X

X

X

X

X

X

History of malignant tumor and aneurysm

X

Family history, medical history and treatment history of TIA, Stroke, hemorrhagic disease

X

Previous history of disease

X

Allergic history

X

History of tobacco and alcohol

X

 RBC

X

X

 WBC

X

X

 Neutrophil

X

X

 Lymphocyte

X

X

 PLT

X

X

 Hb

X

X

 PCV

X

X

 U-LEU

X

X

X

X

X

 U-BLD

X

X

X

X

X

 R-PRO

X

X

X

X

X

 U-Ket

X

X

X

X

X

 OB

X

X

 ALT

X

X

X

X

X

 AST

X

X

X

X

X

 TBil

X

X

X

X

X

 BUN

X

X

X

X

X

 Scr

X

X

X

X

X

 TC

X

X

 TG

X

X

 HDL

X

X

 LDL

X

X

 Fasting blood glucose

X

X

 PT

X

X

X

X

X

 APTT

X

X

X

X

X

 FIB

X

X

X

X

X

 hs-CRP

X

X

 Homocysteine

X

 ECG

X

X

 MRI of brain

X

X

 ADL scale (BI)

X

X

X

 NIHSS

X

X

X

X

X

 mRS before stroke

X

 mRS

X

X

X

X

X

X

 Recurrence rate

X

X

X

X

X

 Cardiovascular and cerebrovascular events

X

X

X

X

X

 Bleeding event

X

X

X

X

 Mortality rate

X

X

X

X

X

 AE and SAE

X

X

X

X

X

 Combined use of drugs

X

X

X

X

X

 Adherence evaluation

X

X

X

X