Effect of high-flow nasal therapy on patient-centred outcomes in patients at high risk of postoperative pulmonary complications after cardiac surgery: a study protocol for a multicentre adaptive randomised controlled trial

Table 3 Schedule Of events

Visit number	Visit 1 Screening	Visit 2 Baseline	Visit 3 Randomisation	Visit 4 Discharge	Visit 5 30 days (+ 7 days) Post-op	Visit 6 90 days (+ 7 days) Post-op
Time interval of visit	Prior to surgical admission (or after admission if in-house urgent)	Surgery admission	During or after surgery and pre-extubation	Day of discharge	30 days (+ 7 days) post-op	90 days (+ 7 days) post-op
Activity
Inclusion/exclusion criteria	X
Informed consent		X
Demographics		X
Past medical history		X
EuroSCORE II and ARISCAT risk assessments		X
EQ-5D-5L and BARTHEL questionnaires		X		X	X	X
Participant and family resource use questionnaire		X		X	X	X
Adverse and serious adverse events assessed (from the point of extubation			X-------------------------------------------------------------X
Inpatient medication log (to start from the point of extubation)			X-----------------------X
Inpatient location log (to start from the point of extubation)			X-----------------------X
Inpatient oxygen therapy log (to start from the point of extubation)			X-----------------------X
Participant location and medication diary				X-------------------------------------X
Randomisation/initiation of HFNT or standard oxygen therapy			X
ROX Index			X-----------------------X
Record of respiratory support escalation			X-----------------------X
Record of post-operative complications			X-----------------------X
Record of intensive care length of stay and re-admissions				X
Record of hospital discharge destination				X
Record of hospital length of stay				X

ISSN: 1745-6215