Table 1 Trial design. The table summarizes the enrolment, allocation, interventions, and assessments in the trail

Timepoint^a

− t₁

0

t₁

t₂

t₃

t₄

t₅

Enrolment

 Eligibility screening

×

 Informed consent

×

 Allocation

×

Interventions

 Topical fluoride application + CO₂-laser irradiation

×

 Topical fluoride application (placebo manipulation)

×

×

×

 Bonding brackets

×

Assessments

 ICDAS score

×

×

×

 SoproLife® Daylight fluorescence

×

×

×

 SoproLife® Blue fluorescence

×

×

×