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Table 1 Previous trials evaluating the role of midodrine for hypotension

From: LIBERATE: a study protocol for midodrine for the early liberation from vasopressor support in the intensive care unit (LIBERATE): protocol for a randomized controlled trial

Author

Year

Patients

Population

Study type

Outcomes

Results

Levine et al.

2013

20

Surgical

Single-center prospective cohort

Dose of IV vasopressor

• Decrease of −1.58 mcg/min of phenylephrine with use of midodrine

Poverno et al.

2016

188

General

Single-center retrospective cohort

Duration of IV vasopressor

• ICU LoS

• Hospital LoS

• ICU readmission

• Midodrine patients required IV vasopressors for 1.2 days following initiation of midodrine

• No change in ICU length of stay

• Increased hospital length of stay with midodrine (12.0 vs. 9.5days)

• No difference in ICU readmission between groups

Whitson et al.

2016

275

Medical

Single-center retrospective cohort

Duration of IV vasopressor

• ICU LoS

• Hospital LoS

• IV vasopressor reinstitution

• Mortality

• Decrease duration of IV vasopressors by 0.9 days

• Decrease ICU length of stay (7.5 days vs. 9.4 days) with midodrine

• Decrease hospital length of stay (21.9 days vs. 24.2 days) with midodrine

• No mortality difference between groups

Santer et al.

2020

136

General

Multicenter RCT

Duration of IV vasopressor

• ICU LoS

• Hospital LoS

• ICU readmission

• Adverse events

• No difference in duration of IV vasopressors

• No difference in ICU or hospital LoS

• No difference in ICU readmissions between groups