Table 8 Ventilation studies
Author | Year | Study type | Centre(s) | Number | Population | Intervention | Control | Primary outcome | Surrogate vs patient-centred | LFU (days) |
|---|---|---|---|---|---|---|---|---|---|---|
Elsharnouby et al. [119] | 2014 | RCT | 1 | 29 | TBSA > 15% | Nebulised heparin sulphate 10,000 IU with NAC | Nebulised heparin sulphate 5000 IU with NAC | Lung injury score | Surrogate | 35 |
Reper et al. [120] | 2002 | RCT | 1 | 35 | TBSA > 20% | HFPV | Conventional mechanical ventilation | FiO2 | Surrogate | 5 |
Chung et al. [121] | 2010 | Pseudo RCT | 1 | 62 | TBSA >30% | HFPV | Low tidal volume ventilation | Ventilator-free days in first 28 days | Patient-centred | 28 |
Mcginn et al. [122] | 2019 | CSWCC | 1 | 48 | Mechanically ventilated with inhalational injury | Nebulised heparin ± NAC and albuterol | Albuterol ± ipratropium | Duration of mechanical ventilation | Patient-centred | NA |
Miller et al. [123] | 2009 | ISWCC | 1 | 30 | Inhalational burn injury | Nebulised heparin sulphate 10,000 IU with NAC and albuterol | Nebulised albuterol | Lung injury score | Surrogate | 7 |