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Table 1 Schematic presentation of the study time line

From: The “Blood pressure and oxygenation targets in post resuscitation care, a randomized clinical trial”: design and statistical analysis plan

  Study period
Enrollment Pre-allocation Post-allocation Follow-up
Timepoint ROSC to randomization 0 h 6 h 12 h 24 h 36 h 48 h 72 h1 96 h1 120 h1 Days 30 and 90
Enrollment
Eligibility screen x           
Informed consent   Legal guardian and next of kin          Patient as soon as possible
Randomization x           
Interventions
Target blood pressure   x      Until invasive BP monitoring is discontinued  
Oxygenation   x      Until extubation  
Active post-TTM fever management   x     TTM device discontinued after 36 or 72 h    
Assessments
Biochemestry2   x    x   x x x x  
Troponin T and CKMB   x x x x x x x    
Biobank samples   x    x   x     
ECG   x x x x x x x x x  
Swan-Ganz-based measurements   x x x x x x x    
Automated pupillometry   x x x x x x x x x  
ABG and VBG   x x x x x x x    
Creatinine clearance        x   x   
CPC and mRS score            x
MOCA score            Only day 90
  1. ROSC return of spontaneous circulation, TTM Targeted Temperature Management, ECG electrocardiogram, ABG arterial blood gas, VBG venous blood gas, SOFA score Sequential Organ Failure Assessment, CPC Cerebral Performance Category, mRS modified Rankin Score, MOCA Montreal Cognitive Assessment
  2. 1: Assements made if patient is still admitted to the ICU