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Table 3 Results of analyses of the GetTested trial. All models included main effects only. Link function is canonical unless otherwise specified. The dash symbol - means model did not converge, except for * where the log risk ratio estimated as 541, indicating separation for one or more covariates

From: Planning a method for covariate adjustment in individually randomised trials: a practical guide

Outcome measure

Summary measure

Adjustment method

Model (variable modelled)

Treatment effect estimate (SE)

Any test (occurred in 35%)

Risk difference

Direct

Identity-link binomial (outcome)

-

  

Standardisation

Logistic (outcome)

0.260 (0.021)

  

IPTW

Logistic (treatment)

0.262 (0.021)

 

Log risk ratio

Direct

Poisson, robust SE (outcome)

-*

  

Direct

Log-link binomial (outcome)

0.797 (0.075)

  

Standardisation

Logistic (outcome)

0.796 (0.074)

  

IPTW

Logistic (treatment)

0.806 (0.075)

Any diagnosis (occurred in 1.6%)

Risk difference

Direct

Identity-link binomial (outcome)

-

  

Standardisation

Logistic (outcome)

0.015 (0.006)

  

IPTW

Logistic (treatment)

0.013 (0.006)

 

Log risk ratio

Direct

Poisson, robust SE (outcome)

0.972 (0.433)

  

Direct

Log-link binomial (outcome)

0.915 (0.412)

  

Standardisation

Logistic (outcome)

0.959 (0.412)

  

IPTW

Logistic (treatment)

0.855 (0.412)