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Fig. 4 | Trials

Fig. 4

From: IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET)

Fig. 4

Statistical procedure. The figure depicts the sequentially rejective multiple testing approach used for the selected confirmatory analyses. The two primary endpoints will be tested in parallel, splitting the overall α equally between the endpoint tests. If any of these two tests shows significant differences, key secondary tests will be conducted using the α-levels as passed on from initial/prior tests according to specified weights

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Trials

ISSN: 1745-6215