Fig. 4From: IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET)Statistical procedure. The figure depicts the sequentially rejective multiple testing approach used for the selected confirmatory analyses. The two primary endpoints will be tested in parallel, splitting the overall α equally between the endpoint tests. If any of these two tests shows significant differences, key secondary tests will be conducted using the α-levels as passed on from initial/prior tests according to specified weightsBack to article page