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Table 4 Novel pragmatic aspects of this trial

From: The Opioid Analgesic Reduction Study (OARS)—a comparison of opioid vs. non-opioid combination analgesics for management of post-surgical pain: a double-blind randomized clinical trial

Clinical situation Intervention Outcomes (important to providers and patients)
• Examines gender differences
• Allows for extraction of any number of 3rd molars during the surgical visit
• Can use any type of anesthesia
• Can use post-operative steroids
• Uses medication protocols which can be followed with existing over-the-counter and prescription formularies
• Follows decreased FDA-recommended doses for acetaminophen
• Allows patients to “get ahead of the pain”
• Follows patients over entire post-operative period (10 days ±5 days)
• Primary outcome is pain experience rather than pain relief
• Assesses ability to sleep and perform daily activities
• Tracks adverse effects
• Explores left-over medication which can be diverted
• Explores future opioid-seeking behavior