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Table 4 Novel pragmatic aspects of this trial

From: The Opioid Analgesic Reduction Study (OARS)—a comparison of opioid vs. non-opioid combination analgesics for management of post-surgical pain: a double-blind randomized clinical trial

Clinical situation

Intervention

Outcomes (important to providers and patients)

• Examines gender differences

• Allows for extraction of any number of 3rd molars during the surgical visit

• Can use any type of anesthesia

• Can use post-operative steroids

• Uses medication protocols which can be followed with existing over-the-counter and prescription formularies

• Follows decreased FDA-recommended doses for acetaminophen

• Allows patients to “get ahead of the pain”

• Follows patients over entire post-operative period (10 days ±5 days)

• Primary outcome is pain experience rather than pain relief

• Assesses ability to sleep and perform daily activities

• Tracks adverse effects

• Explores left-over medication which can be diverted

• Explores future opioid-seeking behavior