Table 2 Secondary variables
Safety parameters | Efficacy parameters | Other variables |
|---|---|---|
Renal function • Cystatin-C • Serum creatinine • Cystatin-C-based estimated glomerular filtration rate (eGFR) • Lowest cystatin-C-based eGFR PODs 1–101 • Serum creatinine-based eGFR • AKIN and RIFLE score2 • Urine output3 Coagulation • Platelet count • International normalized ratio • Activated partial thromboplastin time Inflammation • C-reactive protein Adverse events • (Serious) adverse events/reactions Calculated red blood cell loss Estimated intra-operative blood loss Outcome • Composite of mortality and major post-operative complications (including renal) until day 90 • Length of stay (LOS): LOS in the hospital LOS in the intensive care unit3 Fit for discharge from ICU/hospital4 • Hours on mechanical ventilation • In-hospital/out of hospital mortality (including cause) • (New) renal replacement therapy (RRT) | Fluid administration • Administration of IP volume Fluid balance • Fluid input and output Hemodynamics/vital signs • Heart rate • Temperature • Mean arterial pressure (MAP) • Systolic arterial blood pressure • Diastolic arterial blood pressure • Central venous pressure3 at least one of the following parameters (volume algorithm): • Stroke volume (SV) • Stroke volume variation (SVV) • Stroke volume index (SVI) • Pulse pressure variation (PPV) • Mean arterial blood pressure (MAP) Laboratory data • Arterial blood gas analysis Partial pressure of carbon dioxide Partial pressure of oxygen Bicarbonate Arterial oxygen saturation pH Base excess Lactate Hemoglobin Hematocrit • Central venous oxygen saturation3 • Serum electrolytes Sodium Potassium Calcium Chloride Major post-operative complications5 | Demographic data and medical history • Age • Gender • Height • Weight • Ethnicity • Concomitant diseases and anamnestic baseline characteristics reflecting the surgical risk • Fluid input in the 24 h prior IP treatment start Surgery related data • Main diagnosis leading to surgery • Type of anesthesia • Type of surgery • Time of skin incision/suture Concomitant medication • Antibiotic therapy • Contrast agents • Diuretics • Vasoactive/inotropic drugs • Blood products • Basal infusion administration • Crystalloid solutions/albumin |