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Table 4 Variables and method of analysis

From: Efficacy and safety of modified Bushen Yiqi formulas (MBYF) as an add-on to formoterol and budesonide in the management of COPD: study protocol for a multicentre, double-blind, placebo-controlled, parallel-group, randomized clinical trial: FB-MBYF Trial

Outcomes Hypothesis Variables Analysis method
The frequency and time of AECOPD MBYF improved outcomes Frequency and days (continuous) ANCOVA
The severity of AECOPD Mild, moderate, severe (categorical) χ2 test
CAT score Score (continuous) ANCOVA
Pulmonary function FEV1%predicted, FEV1/FVC, (continuous) ANCOVA
Blood gas analysis Pa (CO2), Pa(O2) (continuous) ANCOVA
mMRC dyspnea scale 0–5 (categorical) χ2 test
6MWT Distance (continuous) ANCOVA
BODE index Score (continuous) ANCOVA
Quantitative scores of TCM syndrome Score (continuous) ANCOVA
Inflammation indexes TNF-α, IL-6, IL-8, IL-10, etc. (continuous) ANCOVA
HPA axis function ACTH, CRH, CORT (continuous) ANCOVA