Baseline | Treatment | Follow-up | |||||
---|---|---|---|---|---|---|---|
Day 0 | Day 7 | Week 2 | Week 4 | Week 8 | Week 12 | Week 16 | |
V1 | V2 | V3 | V4 | V5 | V6 | V7 | |
Sign informed consent | × | ||||||
Randomization | × | ||||||
Medical history | × | ||||||
Intervention | × | × | × | ||||
Primary outcome | |||||||
Treatment failure rate | × | × | × | ||||
All-cause mortality | × | × | × | × | × | × | |
Secondary outcomes | |||||||
Length of hospitalization | × | × | × | ||||
Overall survival | × | × | × | × | × | × | |
Acute exacerbation rate | × | × | × | ||||
Intubation rate | × | × | × | × | × | × | |
mMRC | × | × | × | × | × | ||
SGRQ-I | × | × | × | × | × | ||
Arterial blood gas analysis | × | × | × | × |