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Table 2 Exclusion criteria

From: Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

A. Patients are not eligible for POISE-3 trial if any of the following criteria is present:
1. Patients undergoing cardiac surgery
2. Patients undergoing cranial neurosurgery
3. Planned use of systemic TXA during surgery
4. Low-risk surgical procedure (based on individual physician’s judgment)
5. Hypersensitivity or known allergy to TXA
6. Creatinine clearance < 30 mL/min (Cockcroft-Gault equation) or on chronic dialysis
7. History of seizure disorder
8. Patients with recent (< 3 months) stroke, myocardial infarction, acute arterial thrombosis, or venous thromboembolism
9. Patients with fibrinolytic condition following consumption coagulopathy
10. Patients with subarachnoid hemorrhage within the past 30 days
11. Women of childbearing potential who are not taking effective contraception, pregnant or breast-feeding
12. Previously enrolled in POISE-3 Trial
B. Patients are not eligible for the BP management factorial trial if any of the following criteria is present:
1. Patients with advanced congestive heart failure (New York Heart Association functional class III or IV or left ventricular ejection fraction ≤ 30%)
2. Patients with untreated brain aneurysm
3. Patients with previous history of hypertensive related cerebral hemorrhage
4. Patients undergoing surgery for pheochromocytoma or history of untreated pheochromocytoma
5. Patients who are hemodynamically unstable or requiring vasopressors or inotropic support before undergoing surgery
6. Patients with thyrotoxicosis (i.e., severe hyperthyroidism) requiring perioperative beta-blocker therapy
  1. POISE PeriOperative ISchemic Evaluation, TXA tranexamic acid, BP blood pressure