Fig. 3

SPIRIT figure: participant timeline. Superscript lowercase letter “a” indicates the following: in most centers randomization occurs on the day of surgery prior to the procedure, and always within 24 h before the planned surgery. Superscript lowercase letter “b” indicates the following: in the table, days + 1, + 2, and + 3 refer to days + 1, + 2, and + 3 with respect to the day of surgery. Since randomization most often occurs on the day of surgery prior to the procedure, if surgery is not delayed or canceled, days + 1, + 2, and + 3 after randomization do correspond to postoperative days 1–3