- 1hCG from a peripheral blood sample in women of childbearing potential; if statim hCG is not available, perform urine pregnancy testing
- 2Age, sex, race or ethnic group and BMI
- 3Allergies, comorbidities, and Charlson Comorbidity Index (CCI) and chronic medication
- 4Temperature, blood pressure, heart rate and respiratory rate
- 5Blood count (RBC, WBC, haematocrit, lymphocyte count, platelets), coagulation profile, renal and liver functions (BUN, creatinine, bilirubin, AST, ALT), d-dimer, LDH, troponin, pH, blood gases, sodium, potassium, chloride and glycaemia (other laboratory tests and imaging methods are left at the discretion of each centre)
- 6Counted using the worst values in the first 24 h of ICU stay
- 7D1, CRP, ferritin; D2, CRP; COV-HI is defined as CRP ≥ 150 mg/L or doubling within 24 h from greater than 50 mg/L, or ferritin ≥ 1500 μg/L [11, 15, 16]
- 8CRP (other markers, e.g. procalcitonine, presepsin, interleukin-6 at the discretion of each centre)
- #End of trial visit (or phone call)