Table 1 Inclusion, non-inclusion, and exclusion criteria of the study population

1. Age of 25 to 55 years

1. Persistent arrhythmia with atrial fibrillation

1. Obese (BMI > 30 kg/m²)

2. Scores − 5 or − 4 according to the Richmond Agitation-Sedation Scale (RASS) or 3 to 5 in the Glasgow Comatose Scale

2. Pre-existing atrioventricular block or ventricular tachycardia

2. More than one thromboembolism risk factor

3. Maximal 18 h of coma in ICU admission or during critical care hospitalization

3. Recent acute myocardium infarction

3. Previous venous thrombosis and/or pulmonary embolism

4. Prediction of coma length between 2 and 6 days

4. Provisional or definitive pacemaker

4. Peripheral arterial vascular disease history or suspicion of lower limb arterial insufficiency

5. Prediction of 2 to 12 days of ICU permanence

5. Signals of intracranial hypertension

5. Severe cardiovascular instability and/or use of vasoactive drugs in infusion ≥ 0.5 mcg/kg/min

6. Daily protein consumption standardized for the ICU medical and nutrition teams

6. Neoplasia in chemotherapy treatment

6. Deep coagulopathy (prothrombin time (PT) > 2.5 times the normative values, activated partial thromboplastin time (APTT) > 2 times the normal or platelet count ≤ 50.000/μl)

7. Non-consolidated fractures

7. Heparin intravenous infusion ≥ 2 UI/ml

8. Fever or hypothermia

9. Anemia

10. Neurodegenerative disease

11. Musculoskeletal disease