Table 2 Change in MoCA and neurocognitive domains (test-retest) in the remote and in-person NCT cohorts in control arm participants
Component (maximum score possible) | Remote NCT cohort (n = 4) | In-person NCT cohort (n = 25) | Between groups | |||||
|---|---|---|---|---|---|---|---|---|
Baseline (in-person) | 3 months (remote) | Mean change (SEM) | Baseline (in-person) | 3 months (in person) | Mean change (SEM) | Mean difference in change (SEM) | 95% CI | |
Total MoCA score (30) | 22.75 (1.26) | 23.00 (2.71) | 0.25 (1.11) | 22.40 (3.00) | 21.96 (3.40) | − 0.44 (0.55) | − 0.69 (1.45) | − 3.67;2.29 |
Visual component (8) | 6.25 (0.96) | 6.00 (0.82) | − 0.25 (0.25) | 6.04 (1.34) | 6.04 (1.40) | 0.00 (0.23) | 0.25 (0.59) | − 0.96; 1.46 |
Verbal component (22) | 16.25 (0.50) | 16.25 (1.50) | 0.00 (0.58) | 16.16 (2.46) | 15.72 (2.53) | − 0.44 (0.53) | − 0.44 (1.36) | − 3.23; 2.35 |
Neurocognitive domains testing | ||||||||
Attention and working memory | ||||||||
Digit span—longest forward | 0.04 (1.69) | 0.22 (1.73) | 0.19 (0.45) | − 0.41 (0.70) | − 0.15 (0.93) | 0.26 (0.13) | 0.07 (0.37) | − 0.68; 0.82 |
Digit span—longest backward | 0.26 (0.42) | − 0.21 (0.94) | − 0.47 (0.53) | − 0.26 (0.67) | − 0.25 (0.71) | 0.01 (0.13) | 0.48 (0.38) | − 0.30; 1.26 |
Digit span total (forward and backward) | 0.28 (1.14) | 0.28 (1.17) | 0.00 (0.24) | − 0.28 (0.76) | − 0.24 (0.79) | 0.04 (0.09) | 0.04 (0.24) | − 0.46; 0.54 |
SDMT | − 1.24 (1.46) | − 0.88 (1.46) | 0.36 (0.15) | − 1.42 (1.06) | − 1.19 (1.23) | 0.23 (0.19) | − 0.13 (0.49) | − 1.13; 0.87 |
Total immediate recall (RAVLT) | − 0.78 (0.78) | 0.43 (1.42) | 1.21 (0.69) | − 1.00 (0.98) | − 0.87 (0.99) | 0.13 (0.19) | − 1.08 (0.54) | − 2.19; 0.03 |
Executive functions | ||||||||
Category switching accuracy (verbal fluency) | − 0.50 (1.39) | − 0.77 (2.00) | − 0.27 (0.55) | − 0.38 (1.18) | − 0.35 (1.33) | 0.03 (0.24) | 0.30 (0.64) | − 1.01; 1.61 |
CWI inhibition | 0.62 (0.82) | 0.62 (0.72) | 0.00 (0.26) | − 0.15 (1.20) | − 0.03 (1.11) | 0.12 (0.14) | 0.12 (0.37) | − 0.63; 0.87 |
CWI inhibition/switching | − 1.19 (1.61) | − 0.33 (1.99) | 0.86 (0.63) | − 0.87 (1.54) | − 0.76 (1.69) | 0.11 (0.18) | − 0.75 (0.51) | − 1.80; 0.30 |
Language | ||||||||
Verbal fluency—letter | − 0.79 (0.84) | − 0.62 (0.87) | 0.18 (0.23) | − 0.46 (0.92) | − 0.36 (1.09) | 0.11 (0.17) | − 0.07 (0.44) | − 0.97; 0.83 |
Verbal fluency—category | − 0.70 (1.01) | − 0.34 (1.70) | 0.35 (0.36) | − 0.52 (1.10) | − 0.69 (1.17) | − 0.17 (0.14) | − 0.52 (0.38) | − 1.30; 0.26 |
CWI—color naming | − 0.77 (1.30) | − 0.70 (1.24) | 0.07 (0.37) | − 0.60 (1.36) | − 0.37 (1.19) | 0.23 (0.11) | 0.16 (0.31) | − 0.48; 0.80 |
CWI—word reading | − 0.17 (0.74) | − 0.18 (0.47) | − 0.01 (0.14) | − 0.31 (1.31) | − 0.19 (1.25) | 0.12 (0.06) | 0.13 (0.16) | − 0.20; 0.46 |
Memory | ||||||||
Delayed recall (RAVLT) | − 1.28 (0.73) | 0.12 (1.40) | 1.40 (0.52) | − 1.08 (1.02) | − 1.10 (0.99) | − 0.03 (0.15) | − 1.43 (0.42) | − 2.30; − 0.56* |