Table 3 Trial operating characteristics assuming constant accrual of 16 per week, where \(q=0.95, \underline {c}=0.05\), and \(\overline {c}=0.95\)
\(\theta _{a}^{\star }\) | \(\theta _{w}^{\star }\) | Decide superior | Stop early superior | No stop superior | Stop futile | Stop expect success | Superior following futile | Superior following expect success | Expected sample size |
|---|---|---|---|---|---|---|---|---|---|
0.10 | 0.05 | 0.99 | 0.97 | 0.02 | 0.01 | 0.97 | 0.61 | 1.00 | 1673 |
0.06 | 0.97 | 0.84 | 0.12 | 0.03 | 0.84 | 0.34 | 0.99 | 1959 | |
0.07 | 0.85 | 0.57 | 0.27 | 0.08 | 0.59 | 0.14 | 0.95 | 2251 | |
0.08 | 0.55 | 0.28 | 0.28 | 0.21 | 0.31 | 0.05 | 0.86 | 2412 | |
0.09 | 0.22 | 0.09 | 0.12 | 0.44 | 0.13 | 0.01 | 0.68 | 2353 | |
0.10 | 0.05 | 0.02 | 0.03 | 0.69 | 0.04 | 0.00 | 0.47 | 2129 |