Table 2 Summary of trial scenarios explored

Constant rate of 16 per week (required accrual)

Constant rate of 5 per week (slow accrual)

Ramp-up (slow initially, increasing over course of study)

Uniform between 48 and 72 weeks

0.1

0.05, 0.06, 0.07, 0.08, 0.09, 0.10

0.95, 0.955, 0.96, 0.965, 0.97

1, 0.975, 0.95, 0.925, 0.9, 0.8

0, 0.025, 0.05, 0.075, 0.1, 0.2