Component | Definition |
---|---|
All-cause mortality | All deaths observed among study participants within 6 months since randomization. |
IVROBA | Sudden serious clinical deterioration and cranial imaging suggesting intraventricular rupture of brain abscess after time of randomization. |
Unplanned neurosurgery | Unplanned (re-)aspiration or excision of brain abscess after randomization. This does not include, e.g., planned insertion of ventriculo-peritoneal drain or corrective surgery of dural leak. |
Relapse | a. Cranial imaging showing an increase in brain abscess volume (height × depth × width/2) by 20% compared with maximum volume at time of randomization or formation of additional brain abscesses after randomization. b. Clinical deterioration attributable to treatment failure of brain abscess. This does not include clinical deterioration caused by unrelated infections or other medical conditionsa. c. The local investigator assesses that clinical cure cannot be obtained without IV antibiotics after 4 weeks or longer of oral antibioticsb. This does not include remnant cystic formation at location of brain abscess or residual enhancement on cranial imaging of an otherwise asymptomatic patient [33,34,35,36]. |
Recurrence | New brain abscess formation after end of antibiotic treatment |